Everything You Need To Know About NAD+: The Crucial Role It Plays In Your Mitochondrial Health, How NAD+ Slows Down Aging & Increases Energy, Ways To Increase NAD+ Using Lifestyle, Why NAD+ Precursors May Be Problematic & A Safe, Cost-Effective Oral NAD+ Supplement Strategy.

Affiliate Disclosure

Everything You Need To Know About NAD+
Article-new, Articles, Diet & Nutrition, Health & Wellness, Longevity & Age Reversal, Performance

Look, despite how it seems, I'm not about chasing after longevity at any cost, especially if it means emptying my pocketbook and living hunched over, cold, and libido-less inside some kind of hyperbaric chamber my whole life. Living longer, but not better, is just not something I'm interested in. However, living longer and better? Now that's a different story. 

As you can probably imagine, I've tried tons of different tools, tactics, and techniques to extend life, slow down aging, and increase my quality of life. I discuss many of them in this recent article, and as you can imagine, certain things rise to the surface while many, many more fall by the wayside.

Nicotinamide Adenine Dinucleotide (NAD+) status is one of those big, consistent winners. NAD+ is a molecule of paramount necessity to mitochondrial function, energy production, and yes, aging. Your NAD+ status is one of the most important things to consider not only for your longevity but for your energy and well-being. Anybody who has been sleep-deprived or inflamed or gotten done with a long-haul flight and then taken NAD+ knows exactly what I'm talking about: you freakin' feel it and it amps up energy fast, especially if you're beat up.

But why exactly does NAD+ status matter? And what does it actually do? Why is it so effective at repairing damage and making you feel like a million bucks, even when you're sleep-deprived, exhausted, or beat up?

Basically, NAD+ is one of the molecules in your body’s cells that is involved in redox reactions, which are the reactions that involve the transfer of electrons from one species to another, and ultimately allow for the body's metabolism, ATP production, and critical DNA repair to take place. Researchers think that NAD+ levels (specifically, the “NAD+/NADH ratio”) represent the metabolic activities and health of cells. Thus, if you have a poor NAD+ status (or a low NAD+/NADH), this could signify poor cellular health.

NAD+ status is important for a few reasons. First, NAD+ increases the activity of several important enzymes in the cells such as:

  1.  Regulating sirtuin proteins, which themselves act to increase mitochondrial function and regulate the expression of metabolic genes from your cells’ nuclei.
  2. Regulating the function of Poly (ADP-ribose) polymerase (PARP) enzymes, which are involved in repairing damaged DNA in your cells. I'll talk more about both of these topics below.

Clearly, if you intend to live a long, youthful life that gives you the freedom to pursue activities with abundant amounts of energy, prioritizing NAD+ status is a no-brainer.

But before discussing how to optimize your NAD+ status, it's important to know what causes NAD+ levels to decline.

So you'd better grab your propeller hat because you and I are about to launch into deep science mode…

Understanding The Important Interplay Between PARPs & NAD+

In the intricate world of molecular biology, certain enzymes and molecules play pivotal roles in maintaining cellular health and functionality.

Among these, Poly (ADP-ribose) Polymerases (PARPs) have gained significant attention due to their multifaceted functions in DNA repair, genomic stability, and cellular homeostasis.

PARPs are a family of enzymes found in eukaryotic cells, with PARP-1 being the most extensively studied member. These enzymes utilize NAD+ as a substrate to catalyze the addition of poly (ADP-ribose) (PAR) chains onto target proteins, a process known as PARylation.

In recent years, researchers have unveiled a crucial link between PARPs and NAD+, highlighting the significance of NAD+ status in maintaining overall cellular health. There is real mutual importance. This post-translational modification influences various cellular processes, including DNA repair, transcriptional regulation, and stress response.

The relationship between PARPs and NAD+ is bidirectional, with each influencing the other's activity and availability within the cell. With that said, here are key points to consider:

  • NAD+ as a substrate: PARPs require NAD+ as a substrate for the PARylation process. As PARPs utilize NAD+ molecules during PARylation, the levels of available NAD+ can affect the extent and efficiency of PARP activity. Therefore, maintaining adequate NAD+ levels is essential for proper PARP function. 
  • NAD+ consumption: PARP activity can significantly impact cellular NAD+ levels. Excessive DNA damage or cellular stress can lead to increased PARP activation, resulting in the rapid consumption of NAD+. Prolonged PARP activation and NAD+ depletion can disrupt cellular metabolism, impair energy production, and compromise cellular viability.
  • NAD+ biosynthesis and recycling: Maintaining optimal NAD+ levels is crucial for sustaining PARP activity and cellular health. Cells possess intricate NAD+ biosynthesis and salvage pathways to maintain NAD+ levels. These pathways ensure a constant supply of NAD+ for PARP-dependent processes.

The PARP-NAD+ interplay holds significant implications for overall cellular health and various aspects of human well-being. NAD+ is a vital cofactor that plays a significant role in various biological processes, including DNA repair. And PARPs, a family of proteins essential for the repair of single-strand DNA breaks, require adequate NAD+ levels to function effectively.

DNA damage triggers an upsurge in PARP activity, which, in turn, consumes a significant amount of NAD+. If NAD+ levels are not sufficiently replenished, it could compromise the activity of PARPs, thus impairing DNA repair mechanisms. This leads to the accumulation of DNA damage and instability in the genome, which may potentially escalate into serious health concerns like cancer or premature aging. Therefore, sustaining NAD+ availability is critical as it supports optimal PARP function and contributes significantly to maintaining genomic stability.

NAD+ also plays an instrumental role in cellular energy production pathways. It acts as a coenzyme in redox reactions, facilitating the transfer of electrons in metabolic pathways like glycolysis and oxidative phosphorylation, processes integral to producing ATP, the cellular energy currency.

When NAD+ levels become imbalanced, it can disrupt these energy metabolism pathways, resulting in a decline in ATP production. This energy deficit within the cell can lead to decreased cellular function and might potentially contribute to age-related decline and other metabolic disorders.

Ensuring a balanced NAD+ level is vital for optimal cellular function and energy metabolism, as it helps maintain the cell's capacity to generate energy and effectively carry out its physiological roles.

The Alcohol-NAD+ Connection

Alcohol consumption can be bad news for your longevity due to the negative effects on NAD+ levels and overall NAD+ health. Here's why alcohol consumption is detrimental to NAD+ health:

  • Alcohol causes inhibition of NAD+ synthesis: Chronic alcohol consumption can interfere with the synthesis of NAD+. Alcohol is metabolized in the liver by an enzyme called alcohol dehydrogenase, which converts alcohol into acetaldehyde. This process requires NAD+ as a coenzyme. Consequently, the availability of NAD+ for other essential cellular processes is reduced.
  • Alcohol causes disruption of NAD+ regeneration: Alcohol metabolism leads to the accumulation of acetaldehyde, a toxic compound that can further deplete NAD+ levels. Acetaldehyde is subsequently converted into acetate, which also requires NAD+ for its metabolism. This continuous demand for NAD+ to process alcohol and its byproducts can disrupt the regeneration of NAD+, leading to NAD+ depletion.
  • Alcohol causes increased oxidative stress: Alcohol metabolism generates reactive oxygen species (ROS) as byproducts. ROS can cause oxidative stress, which damages cells and tissues. NAD+ is involved in antioxidant defense mechanisms, such as the production of a key antioxidant called glutathione. Chronic alcohol consumption can deplete NAD+ levels, compromising the body's ability to neutralize ROS and increasing oxidative stress.
  • Alcohol causes impaired DNA repair: NAD+ is crucial for DNA repair mechanisms, which help maintain the integrity of the genetic material. Alcohol-induced NAD+ depletion can impair DNA repair processes, leading to increased DNA damage and potential mutations. This can have long-term consequences, including an increased risk of cancer development.
  • Alcohol causes disrupted cellular signaling: NAD+ also participates in cellular signaling pathways, such as those involving sirtuins. Sirtuins are a class of proteins that regulate gene expression, cellular stress responses, and various metabolic processes. NAD+ serves as a coenzyme for sirtuin activity. Alcohol-induced NAD+ depletion can disrupt sirtuin function, affecting cellular signaling and potentially contributing to metabolic disorders and age-related diseases.

Look, I'm not totally against a glass or two of organic, biodynamic wine, or a healthy cocktail a few times a week. It's important to note that moderate alcohol consumption may not have the same detrimental effects on NAD+ health as chronic or excessive alcohol intake.

However, excessive and prolonged alcohol consumption can significantly deplete NAD+ levels and disrupt various cellular processes, leading to a wide range of health issues like those described above. This means occasionally enjoying some red wine with a meal, as they do in the Blue Zones, is OK, but regular alcohol consumption in larger quantities isn’t a great idea.

The Insulin-NAD+ Connection

Insulin resistance and being overweight can have significant impacts on NAD+ levels in the body.

Insulin resistance occurs when the body's cells become less responsive to the effects of insulin, a hormone that regulates glucose levels in the blood. In individuals with insulin resistance, the pancreas produces more insulin to compensate for the reduced effectiveness.

High levels of insulin can lead to a decrease in NAD+ levels through the following mechanisms such as:

  • Altered NAD+ synthesis: Insulin resistance has been linked to the dysregulation of enzymes involved in NAD+ synthesis. One of the key enzymes, called nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamide into NAD+, may be affected by insulin resistance. Reduced NAMPT activity can result in lower NAD+ levels.
  • Enhanced NAD-consuming pathways: Insulin resistance is associated with increased activity of certain cellular pathways that consume NAD+, such as poly(ADP-ribose) polymerases (PARPs). PARPs are enzymes involved in DNA repair, and their excessive activation in response to metabolic stressors can deplete NAD+ levels. 

Being overweight or obese can also contribute to NAD+ depletion. Adipose tissue, or fat cells, release various proinflammatory substances called adipokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6).

These inflammatory mediators can interfere with NAD+ metabolism and decrease NAD+ levels. Additionally, excess adipose tissue can lead to chronic low-grade inflammation, which further contributes to NAD+ depletion.

Lower NAD+ levels have been associated with several adverse health outcomes, including impaired glucose metabolism, mitochondrial dysfunction, and increased oxidative stress. NAD+ is a critical factor in the regulation of energy metabolism and maintaining cellular health. Insufficient NAD+ levels can disrupt these processes and potentially contribute to the development of metabolic disorders, such as type 2 diabetes, cardiovascular disease, and neurodegenerative conditions.

Finally, aging reduces cellular NAD+ levels. By your 40th birthday, your cellular NAD+ levels could decline around 50%, which is a natural part of getting older. By the time you're 80, your NAD+ may have declined by as much as 80% compared to when you were in your twenties. While NAD+ reduction is a fact of life, you do have the opportunity to influence it through proactive choices (for example, taking something like NAD Regen is one of those things, but I'll discuss that later, below).

Improving NAD+ Status: 4 Lifestyle Hacks

By making smart decisions, you can effectively manage and enhance your NAD+ levels.

A diverse range of options is available, from engaging in physical activities to undergoing IV therapies, and even incorporating oral supplements into your daily routine. The abundance of possibilities allows you to tailor your approach to your personal needs and preferences.

However, it's essential to remember that resorting to pill consumption should not be a workaround for an unhealthy lifestyle. This is not the objective. Instead, establishing a solid lifestyle foundation is what will genuinely bolster your NAD+ levels, making your IV therapies and oral supplements substantially more effective.

Consider the following four “lifestyle hacks” as cornerstones of your efforts to improve your NAD+ status. These foundation elements will help ensure that your endeavors bear the most significant impact possible.

1. Get Regular Exercise

Regular exercise has been found to positively influence NAD+ status through various mechanisms.

One way exercise affects NAD+ levels is by upregulating cellular NAMPT levels which, in turn, act as part of the NAD+ salvage pathway to maintain NAD+ levels.

High-intensity interval training (HIIT) is a form of exercise that involves short bursts of intense activity followed by brief recovery periods. HIIT has gained popularity due to its time efficiency and ability to elicit significant physiological adaptations and shows unique benefits for NAD+ status in particular.

Studies have demonstrated that HIIT can enhance NAD+ levels, and consequently, sirtuin activity (given NAD+ activates these enzymes), more effectively than moderate-intensity continuous exercise. The intense nature of HIIT leads to greater metabolic demands and increased energy expenditure. This energy crisis within the cells activates various signaling pathways, including those involved in NAD+ metabolism.

HIIT has been found to stimulate the expression of certain genes involved in NAD+ synthesis, leading to an upregulation of NAD+ production. Additionally, the metabolic stress induced by HIIT triggers the activation of AMP-activated protein kinase (AMPK), an enzyme that senses cellular energy status. Activated AMPK can promote NAD+ synthesis and sirtuin activity, further supporting NAD-dependent cellular processes.

Moreover, HIIT has been associated with improvements in mitochondrial function. In case you can't remember your high school biology class (and who could blame you?), mitochondria are the powerhouses of the cells and play a critical role in energy production. NAD+ is essential for mitochondrial function, particularly in the process of oxidative phosphorylation, where NAD+ is involved in transferring electrons needed for ATP (adenosine triphosphate) replenishment, the cell's primary energy source. By improving mitochondrial function, HIIT indirectly supports NAD+ metabolism and overall cellular health.

It is worth noting that while HIIT has demonstrated specific benefits for NAD+ status, any form of regular exercise can have a positive impact on NAD+ levels. Different types of exercise, such as aerobic training or resistance training, have also been shown to influence NAD+ metabolism through the upregulation of NAMPT.

In summary, exercise, particularly HIIT, can positively affect NAD+ status by stimulating NAD+ synthesis, activating AMPK, and improving mitochondrial function. By enhancing NAD+ levels, exercise supports cellular processes crucial for overall health and may contribute to longevity and disease prevention.

2. Eat Fermented Foods

When it comes to nutrition, fermented food in particular improves the production of NAD+.

I love fermented foods, such as kimchi, sauerkraut, and kefir, and an added bonus is the positive effect on my NAD+ status.

The fermentation process helps produce lactate by using NADH, thus leading to the production of NAD+. These are very healthy foods and they’re also highly convenient, so keep some in the fridge and add them each day. My personal recommendation? Homemade, authentic fermented sourdough from my wife's recipe.

Here are a few ways fermented foods positively influence NAD+ health:

  • Increased NAD+ production: Fermented foods, such as sauerkraut, kimchi, kefir, and kombucha, are rich in beneficial bacteria or probiotics. These probiotics can promote the growth of NAD-producing bacteria in the gut, such as certain strains of Lactobacillus and Bifidobacterium. These bacteria can synthesize NAD+ from dietary tryptophan, an amino acid, thus increasing NAD+ levels.
  • Enhanced gut health: The gut microbiota plays a crucial role in NAD+ metabolism. Imbalances in the gut microbiome have been associated with reduced NAD+ levels. Consuming fermented foods can help restore and maintain healthy gut microbiota, supporting optimal NAD+ production and utilization.
  • Improved nutrient absorption: Fermentation breaks down complex molecules into simpler forms, making the nutrients in fermented foods more easily absorbed by the body. This increased bioavailability of nutrients may indirectly support NAD+ production, as some essential vitamins and minerals, such as niacin (a precursor of NAD+), are necessary for NAD+ synthesis.
  • Antioxidant activity: Fermented foods often contain bioactive compounds, such as polyphenols and flavonoids, with antioxidant properties. Oxidative stress can deplete NAD+ levels in cells. Fermented foods may help preserve NAD+ pools in the body by reducing oxidative stress and scavenging free radicals.
  • Anti-inflammatory effects: Chronic inflammation can decrease NAD+ levels and impair NAD+-dependent processes. Some fermented foods, like kimchi and sauerkraut, contain beneficial bacteria and bioactive compounds that possess anti-inflammatory properties. By mitigating inflammation, fermented foods may indirectly support NAD+ health. 

In summary, the consumption of fermented foods like kimchi and sauerkraut can boost NAD+ production and improve gut health, while their antioxidant and anti-inflammatory properties protect NAD+ levels. As such, incorporating these foods into your diet is an effective way to support overall NAD+ health and general well-being.

3. Consume Natural Fructose

Dehydrogenase enzymes play a crucial role in various metabolic processes within the human body.

One important dehydrogenase enzyme is NAD-dependent dehydrogenase. This enzyme is responsible for catalyzing reactions that involve the transfer of hydrogen atoms from one molecule to another.

Natural fructose, found in fruits and honey, has been observed to activate certain dehydrogenase enzymes, including NAD-dependent dehydrogenases. This activation occurs due to the presence of specific compounds in these natural sources, such as polyphenols and flavonoids, which have been shown to interact with and modulate enzyme activity.

The activation of dehydrogenase enzymes, particularly NAD-dependent dehydrogenases, by natural fructose can have several benefits for NAD health. NAD is a coenzyme involved in numerous cellular processes, including energy production, DNA repair, and regulation of gene expression. It exists in two forms: NAD+ (oxidized form) and NADH (reduced form).

By activating NAD-dependent dehydrogenases, natural fructose promotes the conversion of NAD+ to NADH. This conversion is an essential step in various metabolic pathways, such as glycolysis and the tricarboxylic acid (TCA) cycle, which are responsible for generating energy in the form of adenosine triphosphate (ATP). Adequate NAD levels are required for efficient energy production, and the activation of dehydrogenases by natural fructose helps maintain the balance of NAD+ and NADH.

Furthermore, the activation of dehydrogenase enzymes by natural fructose also promotes the removal of excess reducing equivalents in the form of NADH. This process helps prevent the accumulation of NADH, which can inhibit certain metabolic pathways. By maintaining appropriate NADH levels, natural fructose supports the overall metabolic balance within cells.

In summary, the activation of dehydrogenase enzymes, including NAD-dependent dehydrogenases, by natural fructose found in fruits and honey, can have positive effects on NAD+ health. It contributes to energy production, maintains metabolic balance, and supports various cellular processes.

4. Use Heat Shock Therapy

Saunas are often associated with relaxation and stress relief, but they may also have potential benefits for NAD. Here's an outline of the significance of using a sauna for NAD+ health and an appropriate frequency for sauna sessions each week:

  • Indirect NAD+ boost: Although this may seem a bit “out there,” there is a good rationale for sauna use indirectly boosting NAD+ levels since saunas have been linked to enhancing overall health and well-being. Regular sauna sessions have been linked to reduced stress, improved cardiovascular function, enhanced blood flow, and increased relaxation. These effects may promote better cellular functioning and optimize NAD+ utilization within the body.
  • Heat stress and NAD+: Sauna sessions subject the body to heat stress, which can activate various cellular responses. Heat stress has been shown to increase the expression of heat shock proteins (HSPs) in the body. HSPs play a vital role in protecting and repairing cells, including NAD-dependent enzymes. By supporting cellular repair mechanisms, heat stress may indirectly contribute to better NAD+ health.
  • Exercise and NAD+: Combining sauna use with exercise may have additive benefits for NAD+ health. Exercise increases NAD+ levels and activates various NAD-dependent enzymes involved in energy production. Sauna use after exercise can enhance recovery, reduce muscle soreness, and potentially optimize NAD-related processes involved in cellular repair and energy metabolism.
  • Frequency: The appropriate number of sauna sessions each week may vary depending on individual preferences, health status, and tolerance to heat. As a general guideline, 2-3 sauna sessions per week can be beneficial for NAD+ health.

However, it's essential to listen to your body and adjust the frequency based on your comfort level and any underlying health conditions. Starting with shorter sessions of about 10-15 minutes and gradually increasing the duration can help your body acclimate to the heat.

It's crucial to stay adequately hydrated before, during, and after sauna sessions. Heat and sweating during a sauna can cause fluid loss, so drinking plenty of water is highly important to prevent dehydration. Additionally, individuals with certain health conditions such as cardiovascular problems or low blood pressure should consult their healthcare provider before using a sauna to ensure it's safe for them.

In summary, sauna sessions can indirectly boost NAD+ levels by promoting better cellular function through heat stress, which triggers protective cellular responses, and by enhancing health benefits when combined with exercise. It's essential to tailor the frequency of sauna use to personal comfort and health status, ensuring proper hydration and medical consultation when necessary.

Your lifestyle, including the factors outlined above, has a major impact on NAD+ status, which is extremely empowering, because you get to choose how you apply yourself on planet Earth using the time God has gifted you with an idealized health span and lifespan, to make your anti-aging a priority.

Improving NAD+ Status With Supplements & Therapies

Once your lifestyle and diet are aligned for optimizing NAD +status, you can consider taking things further, with oral supplementation, IV therapy, and the other strategies I detail here

Personally, I do an NAD+ IV about once a month, wear an IONLAYER patch on long-haul flights or during times of extreme stress, and use oral supplements like BioStack Labs NAD Regen daily.

Why NAD Regen, specifically? Here's a bit of background…

It all started with Tony Robbins. Tony, along with Peter Diamandis, were special guests on my podcast last year, where Tony spoke of this incredible ingredient that could influence NAD+ status like nothing else on the planet. That ingredient was NAD3®.

NAD3® has been investigated using a variety of cell culture and human-based studies. Unlike most NAD+ boosting supplements on the market, NAD3® differs in that it is not an NAD+ precursor. NAD+ precursors like Nicotinimide Riboside (NR), and Nicotinimide Mononucleotide (NMN), raise NAD+ but also use up methylation groups, which may increase homocysteine. In individuals with impaired methylation, either via genetics or chronic disease, this can raise inflammation.

NAD3® on the other hand, does not burden those methylation pathways. Optimal methylation is necessary for homocysteine metabolism/clearance of neurotransmitters, antioxidant, and detox functions. With that in mind, NAD3® may be the safest and most effective strategy to optimize NAD+ status without stressing the body's methylation capacity.

That's all well and good, but what exactly is NAD3®? The “magic” behind NAD3® lies in the complementary action between all three main ingredients:

  • Niacin: Niacin is a known NAD precursor, acting as a critical co-factor for several mitochondrial reactions in cell culture. Biostack Labs added Niacinamide to the NAD Regen formula as Niacin alone was not strong enough on its own.
  • Theacrine: Often compared to caffeine without the negative side effects, Theacrine has various benefits, its inflammation reduction effect being of particular interest for NAD Regen. One of the main reasons you find less NAD in aging individuals is due to age-related chronic low-level inflammation using (or rather sucking up) NAD molecules.
  • Wasabi Japonica (with 6-MSITC being the bioactive substance): This ingredient has been shown to upregulate SIRT1 protein levels. SIRT1 is primarily known for its role in regulating cellular metabolism, and it has been implicated in several cellular processes, including DNA repair, apoptosis, and inflammation.

Unlike other NAD-supportive supplements on the market, NAD3® addresses the root cause of NAD decline. This “root cause” is a production and recycling problem, known as the Salvage Pathway. Niacinamide, Theacrine, and Wasabi Japonica synergistically work together to directly influence the salvage pathway and reduce NAD+ decline. NAD3® has been shown to reduce hallmark signs of aging and positively influence NAD+ in human cells.

Here's the thing, BioStack Labs didn't just leave it at that. In addition to NAD3®, NAD Regen includes carefully selected compounds to support NAD3® in its effect on the salvage pathway and aging. These include: 

  • Resveratrol: Well-known for its antimicrobial, neuroprotective, anti-aging, anti-inflammatory, cardioprotective, and blood-sugar-lowering properties, resveratrol also induces NAMPT release. NAMPT is a critical enzyme in the Salvage Pathway responsible for recycling NAD. By increasing NAMPT alongside the intake of NAD3, you get a one-two knockout punch of both increased NAD+ and improved recycling.
  • Spermidine: Spermidine is best known for removing dead “zombie” (aka senescent) cells from the body in a process known as autophagy. The more “zombie” cells you have, the more at risk you are for elevated levels of inflammation, and higher levels of inflammation are one of the hallmarks of aging. If you can lower your senescent cells by increasing autophagy, you can increase your chances of controlling aging and longevity. Spermidine has also been linked to protection against DNA damage, stabilizing mitochondrial DNA, as well as support healthy skin and hair. The patented form of spermidine called Yüth found in NAD3® Regen is a powerful anti-aging compound in its own right, but combined with the other ingredients here, now you're looking at possibly one of the greatest oral anti-aging supplements on the market.
  • BioPerine: Finally, BioPerine is added to enhance the absorption of all these powerful ingredients. BioPerine has been used as a potent bioavailability enhancer for over 20 years, and I'm impressed to see it in this formula. 

Finally, I want to bring notice to something that is missing from the NAD Regen formula: bullcrap fillers. Seriously, it is such a relief to see a supplement that forgoes all the unhealthy and often unavoidable fillers like magnesium stearate, anti-caking agents, etc. Regardless of the supplement's effectiveness, I deeply appreciate any company willing to go the extra mile just to leave junk out of their product.

To reiterate, NAD Regen is the only formula on the planet that addresses this issue and fixes any “maintenance” problems so that NAD+ production continues and NAD+ recycling is optimized.

As of yet, I haven't found a single other oral supplement that compares to NAD Regen in safety or effectiveness.

It forgoes the methylation burden of your typical NAD precursor supplements like NR or NMN, NAD+ is boosted by going to the root cause of NAD+ decline rather than simply addressing the symptom, and other compounds in the blend boost NAD+ recycling, increase autophagy and reduce DNA damage, and ensure high bioavailability of the product.

The intelligence and care that went into the development of this product are frankly remarkable, consistent, and impressive.


As you've just discovered, if you are 30 years old or older and care about longevity, there are a few factors more important than your NAD+ status. 

I hope this article will serve as your “go-to” blog on NAD+ status, to refer back to and share with anybody you know who wants to start biohacking.

There are a plethora of things one can do to influence NAD+ status, through better lifestyle choices. As a reminder, regular intense workouts, a weekly HIIT training session, fermented foods, getting lean, and an optimized sleep routine all directly or indirectly improve NAD+ status.

NAD+ IV therapies and NAD-supportive supplements are how you optimize things after getting your lifestyle right, and I have found no better oral supplement on the market for this purpose than NAD Regen.

In summary:

  • NAD+ levels (expressly, the “NAD+/NADH ratio”) represent the metabolic activities and health of your cells. A better ratio means better health.
  • NAD+ increases the activity of several important enzymes including sirtuin proteins and poly (ADP-Ribose) polymerase (PARPs) enzymes.
  • PARPs and NAD+ dance an interplay with significant implications for DNA damage, cellular energy metabolism, and human health as a whole.
  • Alcohol has a significant effect on reducing your NAD+ and should be moderated as much as possible. 
  • NAD+ can enhance insulin sensitivity, making it a potential factor in preventing metabolic diseases like diabetes. 
  • High-intensity exercise, fermented foods and fructose from honey or fruit, and heat-shock therapy (sauna) are some of the best ways to optimize NAD+ using lifestyle factors.
  • Beyond lifestyle factors, you can increase NAD+ using techniques such as NAD+ IV treatments, NAD+ patches, and oral supplementation, which I detail here.
  • NAD Regen is the oral supplement I use after being recommended NAD3® supplements by Tony Robbins. NAD3® is safer and more effective than typical NAD precursor style supplements because it does not burden methylation, and instead addresses the root cause of NAD+ decline: the salvage pathway.
  • In combination with the other powerful anti-aging ingredients in NAD Regen, the product both supports NAD+ production and recycling while protecting against DNA damage and instigating autophagy.

So what's the upshot for you…?

Namely, improved longevity and abundant youthfulness so you can live a life that is very much on your terms, with the ability to take advantage of every single day.

For even more information about the science behind NAD+ and the NAD Regen supplement I take, you can visit BioStack Lab's site here. Is NAD+ new to you? Do you have any additional questions for me? Let me know in the comments below!

Ask Ben a Podcast Question

8 thoughts on “Everything You Need To Know About NAD+: The Crucial Role It Plays In Your Mitochondrial Health, How NAD+ Slows Down Aging & Increases Energy, Ways To Increase NAD+ Using Lifestyle, Why NAD+ Precursors May Be Problematic & A Safe, Cost-Effective Oral NAD+ Supplement Strategy.

  1. amy says:

    Please comment on the NAD testing available thru Jinfiniti. Have you done any before and after? They also have some other unusual and interesting labs specifically around autophagy, redox and anti-aging…– I would love to see you do a podcast/investigation. thanks.

  2. Josh says:

    Can anybody explain to me why I would take this product that has quite literally zero studies to show that their product works as advertised? At least their competitor Nuchido or w/e literally did studies that shows they raised NAD levels over just taking NMN or NR….

  3. mandy lin says:

    hi i have been using subq dosing for a while of pure nad+ my life changed i just want to know what i would notice and why i would need the switch

  4. Matthew Langford says:

    Thank you for the wonderful insight on NAD+ and NAD Regen.
    I’m looking forward to putting these recommendations to use and determine the overall effect on my energy and sleep.

  5. Eric says:

    Hey, brother. I appreciate the vast knowledge you have, and that you share with us.

    I was reading on the Biostack website that this NAD regen can replace my NMN supplement (specifically, a liposomal NMN by CODEAGE). So, I was curious to the How and Why…if you could please direct me to a resource that would help me to better understand. Thank you!

  6. Jay says:

    Here’s the problem that many of us run into when presented with one of these supplements. The greater the number of intrinsic ingredients, the greater the potential for an individual to have a negative reaction or allergy to one of them. For example, I hurriedly followed the link to purchase Regen NAD3. But, before doing so, I checked the label for ingredients as I always do prior to purchasing a new supplement. Well, I found that one of the ingredients is spermidine. Spermidine has unfortunately caused me to experience heart palpitations/arrhythmia in the past, apparently due its effect on my over-reactive adrenergic heart receptors. These receptors tend to get over-stimulated by a host of other things as well, such as high-dose caffeine, maca root, boron, saw palmetto, creatine, turmeric, and the list goes on.

    So, the use of the supplement becomes an impossibility for me personally. if you were to recommend a second source of NAD3 or perhaps another NAD+ stimulating compound, which one would that be?

  7. Craig Dodd says:

    So, if you take this product, it replaced the 1gm of NMN that Sinclair recommends? I find that 1gm gives me so much more energy.

    1. Nikki says:

      Same question as Craig Dodd. I love my NMN from DO NOT AGE. Please lmk if this would replace that and my TMG. Thanks

Leave a Reply

Your email address will not be published. Required fields are marked *