Welcome to Ben Greenfield's Weekly Roundup!
In this weekly post, I share with you my most interesting discoveries of the week, including the latest news on the fronts of fitness, nutrition, health, wellness, biohacking, and anti-aging research. I also recap my upcoming events and special announcements so you can keep up with opportunities to learn, giveaways, discounts, and more!
New Discoveries
Feel “Weird” During NAD IV Therapy? *These* 3 Tips From a Regenerative Medicine Pioneer Make Your Treatment Smoother, Faster & More Effective ⚡
If you've spent any time around longevity clinics, recovery centers, or high-performance circles lately, you've probably seen people hooked up to an NAD IV.
NAD (nicotinamide adenine dinucleotide) is one of the most important molecules in the body for turning food into energy and powering cellular repair, which is why these infusions are used to boost energy production, mental clarity, recovery, mitochondrial health, healthy aging, and even resilience after travel, stress, or overtraining.
The thing about NAD infusions is that they can feel intense. Some people experience nausea, flushing, chest pressure, restlessness, or an odd “something feels off” sensation during the drip. It's why some who try it never go back.
Fortunately, there are ways to make the process much smoother, including these strategies from regenerative medicine pioneer (and this Saturday's podcast guest), Dr. Joseph Purita.
1. Take TMG Before Your Infusion
TMG (trimethylglycine), also known as betaine, acts as a methyl donor. During NAD infusions, your body produces nicotinamide (NAM), which must be cleared efficiently through methylation by an enzyme called NNMT (nicotinamide N-methyltransferase). This process consumes methyl groups and can temporarily elevate homocysteine, which signals that methylation pathways are becoming depleted, reducing the body's ability to clear nicotinamide efficiently and contributing to side effects. Taking TMG beforehand may help support methylation pathways and improve tolerance.
2. Sip Coffee During The IV
This one surprises people. The caffeine in coffee can potentially upregulate NMNAT2 (nicotinamide mononucleotide adenylyltransferase 2), a key enzyme involved in recycling NAD precursors back into usable NAD+. Caffeine also blocks adenosine receptors, which may help reduce some of the sluggish or uncomfortable sensations people experience during infusions.
3. Use Red Light To Photoactivate The NAD
Another advanced strategy Dr. Purita uses at PUR-FORM is exposing the NAD solution to red light before it enters the IV bag. This can increase production of NADH, the reduced form of NAD, which can then be rapidly recycled back into NAD+ through mitochondrial complex I to support cellular energy production.
My take is that NAD IVs can be a fantastic tool, but the delivery process makes a big difference in the results.
If you’ve struggled with side effects or want to get more from the experience, these three simple tweaks might make all the difference.
If you want to go deeper on NAD, advanced treatments like IVs, and other regenerative medicine protocols, you can check out the resources below (and don't forget to tune into Saturday's show with Dr. Purita by subscribing to my podcast on Spotify, Apple Podcasts, or YouTube):
- Everything You Need To Know About NAD+: The Crucial Role It Plays In Your Mitochondrial Health, How NAD+ Slows Down Aging & Increases Energy, Ways To Increase NAD+ Using Lifestyle, Why NAD+ Precursors May Be Problematic & A Safe, Cost-Effective Oral NAD+ Supplement Strategy.
- The NAD Supersode: All Ben’s Crazy Questions About NAD, Natural Ways To Increase NAD, Living To 120 With NAD & Much More With Matt Titlow & Michael Roberts.
- Could NAD IVs Be Bad For You (& How To Boost NAD Naturally), With Dr. Nichola Conlon.
- The AMAZING Future Of Regenerative Medicine, The New Sexier Alternative To Stem Cells, Where You Should Get Peptides (& The Best Peptides Stacks) & More With Dr. Matt Cook.
- Peptides, Biologics & Small Molecules You’ve *Never Heard Of* For Sleep, Mitochondria, Kidney Health & More, With Jim LaValle.
- Ben Greenfield’s Game-Changing Biohacks & Health Trends of 2025: 10 Science-Backed Strategies For Revolutionizing Human Performance.
- ONE Tiny Blood Spot = HUNDREDS (!) Of Biomarkers, Age & Disease Prediction With Dr. Matt Dawson.
Your 2026 Mother’s Day Gift Guide Has Arrived! I Hand-Picked These Gifts for Your Mom (+ Laser Lights & EXOSOMES?!) 🩷
Panicking over what to get Mom this Mother’s Day and have no idea where to start, or just don’t want to give her another *boring* gift this year?
Skip the usual suspects: flowers that fade within three days, candles that quickly burn out, and bath bombs that stain your bathtub cotton candy blue.
The special woman in your life deserves something incredible that *actually* lasts. I mean, she changed your diapers, right?
So… I put together my 2026 Mother's Day Gift Guide with one thing in mind: helping you give Mom a vetted present that delivers her fresh energy, better recovery, unparalleled sleep, and long-term health.
🎁 Just a few highlights from the guide:
- Sunlighten mPulse Sauna: Personalized infrared sauna sessions for recovery, relaxation, detox, and deeper sleep.
- Apollo Neuro: A wearable designed to support calm, stress resilience, and better sleep.
- Young Goose Gift Sets: Advanced skincare protocols focused on repair, cellular energy, and skin longevity.
- Pendulum Metabolic Daily: Clinically studied probiotics for gut health, metabolism, and steady energy.
- LIFEprint HTMA Test: At-home testing to expose hidden mineral imbalances, stress patterns, and energy roadblocks.
- Boundless: My bestselling health optimization book packed with strategies for hormones, metabolism, longevity, and peak performance.
So, what are you waiting for?
Scroll through, find Mom a memorable gift, and use the discount codes listed in the guide for extra savings on these time-sensitive deals.
👉 Grab the Perfect Gift for Mom
This Week in Health & Performance: What the Latest Research Says
💪⏳ Fasting & Muscle Loss—Not So Fast: Yes, fasting can contribute to muscle loss, but research shows resistance training dramatically improves your ability to preserve lean mass, even on fasting days. The lesson: if you fast, lift (read the study).
🌙📉 Simple Meal Timing for Better Metabolic Health: If you struggle with blood sugar swings, stubborn body fat, low HRV, or elevated resting heart rate, one of the simplest interventions may be avoiding food for roughly 3 hours before bed and delaying your first meal for a few hours after waking. Circadian-aligned eating continues to show powerful benefits (full study here).
🐟🧠 What Is “Sardinemaxxing”?: The internet’s latest nutrition trend focuses on eating more sardines for their rich supply of omega-3s, protein, calcium, selenium, and low-mercury convenience. Odd name, but still a smart food (read more).
🏆💉 The “Enhanced Games” Debate Heats Up: A provocative new take on the drug-permitted “Enhanced Games” raises questions about ethics, athlete health, and where the future of elite sport may be heading. Whether you see progress or madness, it’s worth paying attention (get the full story).
Key Takeaway: This week’s research points to a familiar truth: fundamentals still win. Lift weights if you fast, align meals with circadian rhythms, eat nutrient-dense whole foods, and be cautious whenever shortcuts promise superhuman performance.
Want to dive deeper? Click the links above to explore the research, and click here to follow me on X for all the latest health and performance news hot off the press! 
Product Of The Week
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You’ve heard, “You are what you eat…”
But the real truth is that you are what you absorb, and even the cleanest, most nutrient-dense diet can fall short if your digestion isn't optimized.
Enzyme production naturally declines with age, stress, travel, and hard training, which means you could be extracting far less nutrition from your food than you think, impacting your recovery, energy, muscle building, and overall performance.
That's where BIOptimizers MassZymes comes in.
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Ready to actually use what you eat?
You can snag 15% off MassZymes with code BEN15 at checkout here.
Podcasts I Recorded This Week:
Could NAD IVs Be Bad For You (& How To Boost NAD Naturally), With Dr. Nichola Conlon
How To Be A Better, More Present Father (& Not Get DAD-BOD!) with John Schott
The Latest Content I Was Featured On This Week:
My Article Feed:
My full article feed and all archives of my articles are here.
Upcoming Events:
Boundless Live Tour Presented by FormulaIQ | Summer 2026
Join the world premiere of Boundless: The Man Who Became Human, a new feature documentary that follows 20 years of body optimization colliding with life's immeasurable moments—marriage, family, and faith. Experience a live podcast recording and intimate Q&A with my family and me in Los Angeles, New York, Austin, and Moscow, ID, one night in a room full of people chasing the same thing. Purchase tickets here.
Health Optimisation Summit | September 11–13, 2026
I'm speaking at the Health Optimisation Summit in London (September 11–13, 2026) at the Business Design Centre. This isn't your average health conference. HOS unites the best minds in biohacking, longevity, nutrition, fitness, and medicine, with one goal: to actually make people healthier. With 35+ world-class speakers, 120+ cutting-edge brands, and 4,000 like-minded people all under one roof, it's two days that could genuinely change how you approach your health. Get your ticket here and use code BEN to save 10% off registration!
Eudēmonia | November 5–8, 2026
I'm speaking at Eudēmonia (November 5–8, 2026, in West Palm Beach, FL), a prevention-focused, science-based health, well-being, and longevity summit designed to add years to your life and life to your years. Across 3 days and 15 venues, you'll experience 200+ talks from 120+ experts, 300 treatments, and 160+ brands covering everything from biohacking, longevity, and hormonal health to gut health, brain health, peptides, mobility, and more. I'll be leading a talk and a movement session alongside some of the brightest minds in health today. Use code BGREENFIELD-EUD-100 for $100 off when you register here!
The Boundless Couples Retreat | November 10–14, 2026
Ready to reconnect and recharge with your partner in paradise? Join the Greenfields at the stunning Prana Maya resort in Belize for the Boundless Couples Retreat, November 10–14, 2026. It's a five-day, all-inclusive escape designed to deepen your relationship, restore your vitality, and create memories that last a lifetime. From relaxation and adventure to intimate relationship coaching with Jessa and me, every detail is crafted to send you home with a stronger bond and a reinvigorated spirit. Spots are limited, so discover more and secure yours here today!
The Manzo x Ben Greenfield Table Private Dinner | Throughout 2026
If you want to taste one of the world's rarest cuts of beef and experience my North Idaho biohacking compound firsthand, my family and I are hosting The Manzo x Ben Greenfield Table, an intimate, chef-catered VIP dinner on a few limited 2026 dates. The evening includes biodynamic wine, a live cooking demo, a multi-course Piedmontese feast finer than Wagyu, and a night of deep sleep in an EMF-free, fully grounded, circadian-optimized guest room. Anyone who reserves a half or whole Piedmontese bull from Manzo qualifies for a spot, so reserve your allocation and dinner here.
Stay tuned for future updates—and you can always keep up with my LIVE appearances by checking out bengreenfieldlife.com/calendar!
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Cheers,
Ben
