The Next Big Anti-Aging Drug: Everything You Need To Know About “NAD”.

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Anti-aging, Body, Diet & Nutrition, Longevity & Age Reversal, Podcast, Podcast-new

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Click here for the full written transcript of this podcast episode.

Scientific American recently published the article “Beyond Resveratrol: The Anti-Aging NAD Fad“, an article that proposes that…
…”recent research suggests it may be possible to reverse mitochondrial decay with dietary supplements that increase cellular levels of a molecule called NAD (nicotinamide adenine dinucleotide)”…

…and also that…

…”the mitochondria in muscles of elderly mice were restored to a youthful state after just a week of injections with NMN (nicotinamide mononucleotide), a molecule that naturally occurs in cells and, like NR, boosts levels of NAD”…

Since that article was published I've received an onslaught of questions about this mysterious molecule called NAD.

It just so happens that a friend of mine, Thomas Ingoglia, known as one of the best NAD scientists on the planet and is also in contact with the best NAD clinicians on the planet – both with decades of experience second to none. I consider Thomas himself to be one of the most knowledgeable and frequent users of NAD I've ever met, and one of the few that has been playing around with NAD in combination with cryotherapy, blueberry extract, hyperbaric oxygen and other “biohacks” to completely turn him around from being bed-ridden sick and losing half his family in a car crash to being in the best health of his life, including crushing his first Spartan race with me last year (prior to which took high doses of NAD).

Problem is, most NAD clinical researchers are all underground at the moment. The FDA doesn't look kindly at NAD supplement companies and integrative doctors, they are quite skeptical of naturopathy, and their first impulse is to turn these things and others into patentable drugs because that’s the language the FDA speaks. Plus, NAD can be dangerous. Thomas even knows a guy personally (ironically, a Phd in toxicology that poisoned himself due to his own error) who hospitalized himself experimenting with the substances we’re going to be talking about in this podcast episode. So you need to proceed with caution and with the formal clinical information Thomas has opened my eyes to.

Along with Thomas, today's podcast features Dr. Ross Grant, Phd. Dr. Grant is perhaps the most prolific authors in the field of NAD, and he specializes on NAD in the brain. He started researching NAD research back in 1994 while being laughed at, when no one was doing NAD research.

Dr. Ross Grant is Clinical Associate Professor at the University of Sydney Medical School and CEO of the Australasian Research Institute, Sydney Adventist Hospital. A biochemical pharmacologist with a Ph.D. in Neurochemistry/Neuropharmacology, Dr. Grant’s research is focused on NAD – specifically the role of oxidative stress – e.g. emotional stress, diet, and exercise – and NAD metabolism on brain cell death and cellular degeneration. A secondary interest is in the effect of exposure to novel nutritional components, such as polyphenols, on human cellular response to oxidative stress, with a goal of detecting and correcting early degenerative biochemical changes associated with aging-related degenerative disease.

Dr. Grant is a member of the Australian Society for Medical Research (ASMR), Australian Neuroscience society (ANS), Australian Society of Clinical & Experimental Pharmacology and Toxicology, Nutrition Society of Australia (NSA). With forty-eight articles published in peer-reviewed scientific journals, Dr. Grant is perhaps the most prolific author in the field of NAD research.

In addition to Dr. Grant, we are joined by Dr. Philip Milgram, MD, from the NAD Treatment Center in San Diego, California. Dr. Milgram recovered from his own challenges with addiction and now helps other people in recovery from addiction, specifically by using NAD protocols. He trained in 1991 with Vernon Johnson, the man who coined the term “Intervention”. He was certified as a Prevention Specialist by the Certifying Board of Alcohol and Drug Counselors (CCBADC) in 2001, and has three degrees in counseling from UCSD; in Counseling and Interpersonal Communication, Alcohol and Drug Counselor and Advanced Intervention.

In addition to NAD Treatment Center, Dr. Milgram served as the original Medical Director of Confidential Recovery and the Pemarro Detox Center. He has also served as the Medical Consultant for The Soledad House Recovery Home for Women and ABC Recovery since they opened. He is a member of the attending staff at Scripps Memorial Hospital in La Jolla and Board Certified in Obstetrics and Gynecology. Dr. Milgram is a member of The American Society of Addiction Medicine, the California Association of Addiction Medicine, International Doctors in AA, Like-Minded Docs Addiction Medicine, The American College of Preventive Medicine, the American Society of Anti-Aging Medicine, and the American Nutraceutical Association.

During our discussion, you'll discover:

-An easy explanation of what exactly NAD is and what it does inside your body…

-The protocol Thomas used to go from being addicted to opiates and chronically fatigued to completely healed…

-How NAD can break addictions to alcohol, food, opiates and more…

-The relationship between anti-aging and NAD…

-The important difference between Nicotinamide Riboside vs. Nicotinamide (NMN) vs. NAD+…

-The best way to “flood your body” with NAD, and why grapes and blueberries are so important when it comes to your NAD levels…

-What kind of compounds, foods and lifestyle strategies enhance the effect of NAD…

-How NAD can increase your time to exhaustion during exercise by over 15%…

-How Thomas used NAD to enhance his performance in a Spartan race…

-The best way to test your own NAD levels…

-How NAD can be used in the treatment of Lyme Disease…

-The best resource for people to delve more into NAD research…

-And much more!

Resources from this episode:

Book by Nady Braidy: NAD+ metabolism in neurodegeneration and ageing

NAD Treatment Center in San Diego, California

Nicotinamide supplements (be careful with dosage on this, as we discuss in podcast!)

Nicotinamide Riboside supplements (dosage also discussed in podcast)

Resveratrol supplements

Wild blueberry concentrate supplements

Thorne Resveracel (resveratrol + NAD)

Pau D' Arco Bark tea that can be brewed and blended with fats such as coconut oil or krill oil to create NAD-based phosopholipids


NAD⁺ infusions are an experimental treatment, and do not have FDA approval and haven't been fully evaluated. To the best of our knowledge there are no lasting problems. This IV therapy has been around for decades but it has mostly been underground. Over ten thousand patients have had NAD⁺ intravenous treatment  but this is not a panacea and not everyone is going to have positive results.
Do you have questions, comments or feedback for Dr. Grant, Dr. Mingram, Thomas Ingoglia or me? Leave your thoughts below and one of us will reply!

Ask Ben a Podcast Question

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208 thoughts on “The Next Big Anti-Aging Drug: Everything You Need To Know About “NAD”.

  1. Chuck Frasher says:

    Wonderful presentation. Thank you so much. I’m trying to heal a damaged pancreas with some extended fasts (5 days) followed by primarily a whole food plant based diet (low in AGEs) with *some* chicken and fish for phospholipid DHA and EPA and to also rev up IGF-1 after a fast for tissue repair. I also take R lipoic acid, pyridoxal-5-phosphate, Carnosine, and Benfotiamine to reduce the accumulation and damage from AGEs. So after my next fast I’ll be taking BPC 157, CoQ10, Resveratrol, and NAD+ shortly after initiating refeeding. This has been very helpful!

  2. Em says:

    Does anyone know about NAD+ infusion’s effects on the adrenals? I have very weak adrenals (low cortisol and Chronic fatigue and crash from exercise and fasting). I had an NAD + infusion yesterday and today I feel like crap and trying to determine if it elicited a crash.

  3. Gary says:

    I have just purchased quicksilvers nad platinum that has nmn in it and was excited about starting to take it. However, I was just reading some articles about nmn causing cancer. Surely they are flawed studies. Curious as to whether you have seen those articles and your thoughts. thank you.

  4. Michael Radford says:

    I have undergone well over 10 NAD IV Infusions at 1000mg for treatment of lymes disease, now that I have gained my life back, Ask Me Anything!

    [email protected]


    1. Lizabeth Shirley says:

      I am so happy for you 👍

    2. Carmen says:

      What is the frequency of your treatments? Once a month?

  5. Edgar V says:

    Ben, have you ever tried subcutaneous injections of NAD+? Would a shot be just as helpful as an IV or would it be too uncomfortable?

    1. Yes, it is amazing. I discussed it in my recent podcast with Dr. Cook:…

      1. Tyler says:

        Hey Ben, I just started doing SubQ injections of NAD. I haven’t noticed anything yet and I understand there is a bit of a loading phase with NAD so curious your thoughts on how many mg’s it should take to get over the hump.

        So far I’ve taken about 300mg’s over the course of a two day period and have 700mg’s left. If you were me should I consider taking the rest in a short period of time or 100mgs every week or so?

    2. Timmerman Bethany says:

      What a great question! I’m looking for this answer as well!

  6. Anthony says:

    Hi Ben, I am having a hard time getting into contact with Dr Koniver and would like to start his at home NAD+ regimen. Do you have updated contact info for him so I can begin the at home treatment. Thank you

  7. Steve D says:

    Hey there,

    I have two questions

    1) Once you start taking nmn (and resveratrol) do you need to continue taking them for the rest of your life? Im no where near 50 yet, but considering trying this for a month or so and seeing the effects, however I’m concerned on the effects of stopping if I so choose to do so.

    2) Where do you get this stuff at a realistic price? This podcast mainly talked about IVs, I really am not a fan of needles and doubt theres any doctor in my area doing this. Amazon sells nmn at like 125mg serving sizes, and thats no where near enough, I would have to take 5-10x that , thus turning a $50+ 30 day supply into a 5 day supply.. Doesnt seem reasonable

    1. I like Tru Niagen and Thorne NiaCel. Pau d' Arco tea is also a natural source. Check out this podcast (and shownotes) for more info:

      1. Curtis says:

        Looks like Thorne has discontinued the Niacel line; I wonder why? Also, I am wondering about the possibility of NR and NMN depleting Methyl groups as I have the MTHFR variant…was a bit annoyed with Phil when he made the comment about it improving the MTHFR gene function and then didn’t dig into it…Is there any research on this that anyone is aware of???

        1. If you simultaneously support yourself with MTHF and other methyl precursors, such as dark leafy greens, organ meats and magnesium should be okay. In regards to Niacel: Looks like they are discontinuing 125mg, but 250mg is still available. They also have a cool product called ResveraCel that's worth checking out.

          1. Curtis Radke says:

            Well, after experimenting with Niagen I’m gonna go ahead an call it; Bad Idea for MTHFR folks. I was taking 4 a day for 3 days then 1 a day for 2 more. It was kind of a perfect storm scenario though so I can’t blame it entirely on NR…On the 4th day wound up very hypoglycemic and cut the nr back to the aformentioned 1 a day. Sidenote: I take 2x daily thorne Methyl guard plus and 2 x daily AOR Advanced B…so I get about 3 mg of B12 daily plus the other Methyl items. 5th day took a Rabaprazole (sp?) an antacid that also depletes b12, as I was going to be drinking…woke up after the party with the worst ever hangover (only drank about 6-7 drinks) super hypo glycemic and continued to repeatedly go hypo glycemic repeatedly over the next 5 days with severe debilitating anxiety, dizziness, thinking issues, other weird brain stuff, breathlessness, super tired etc etc. On the verge of going to the hospital several times…when someone suggested look at my b12 (I wasnt’ thinking I was low given what I supplement) I decided to try a few megadoses of b12 with some TMG…one hour later, blood sugar corrected, dizzyness 90% reduced as where other symptoms…3 days later after much b12 supplementation and me feeling much better, (because I am stupid), I decide to see what an NR will do to me… pill later:right back into hell with the aformentioned symptoms!!!

    2. Was the cycling question about NMN and Res. answered? Can you go on and off or are you on for life? Expensive and controversial, but if you are on for life with poor effects of going off the supplement that seems to be the deciding factor not to try it. As a practicing veterinarian, I have tried it on old dogs with no obvious effects (purely anecdotal.)

    3. Dustin says:

      you can buy NAD injections and Sub q NAD at ! These guys have everything from Meyers cocktail to B12 with MIC and Glutathione. They even sell NAD cream that my son uses for his psoriasis . Works like magic

  8. Great podcast on Joe Rogan! Does is make you a nervous at all giving your kids all those supplements and medication?

    I’d like to ask David Sinclair himself whens best to start boosting your NAD levels!

  9. Mr.Saito says:


    Please see the study below, which found that NR supplementation of healthy young rats led to NEGATIVE physiological markers and DIMINISHED exercise performance. Perhaps NR supplementation may benefit an ill individual but not a healthy one. More studies are definitely needed.

    “Nicotinamide riboside supplementation DYSREGULATES redox and energy metabolism in rats: Implications for exercise performance.

    These findings support the prevailing idea that exogenously administered redox agents in heathy populations might lead to ADVERSE effects and not necessarily to beneficial or neutral effects. ”

    1. Pavel says:


    2. Luke says:

      Intravenous NAD+ therapy changed my life. Among many other things, my exercise performance soared for several weeks following one 8-hour dose.

      1. Carmen says:

        How many MG did you do? Are you continuing treatments?

    3. thato amelia says:

      My first symptoms of ALS occurred in 2014, but was diagnosed in 2016. I had severe symptoms ranging from shortness of breath, balance problems, couldn’t walk without a walker or a power chair, i had difficulty swallowing and fatigue. I was given medications which helped but only for a short burst of time, then I decided to try alternative measures and began on ALS Formula treatment from Tree of Life Health clinic. It has made a tremendous difference for me (Visit w w w . treeoflifeherbalclinic. com ). I had improved walking balance, increased appetite, muscle strength, improved eyesight and others. ]

  10. Mark says:

    So I have been waiting a long time to find the IV’s and looks like now the company I was buying from decided to start selling on Amazon . Super Cheap too. Now we can get it shipped direct to the house.

    NAD solution (10ML) NAD LLC via @amazon

  11. NAD Lab UK says:

    Will definitely be increasing my sprouts and broccoli for that natural boost.

    The debate around the most effective supplement (mainly NAD, NMN and NR) seems to be based around the amount of research and testing in to each. Which one is best at entering the cells!? I don’t think we have answered this question.

    For now, the best approach would be to try them all and see what is most effective for you.

    Exciting times!

  12. wow nice episode. I’m looking for NAD in my current amazing country which is Iceland but there is none here, I think there is some legal issues. The most similar thing I found is Niacin by Now Foods so I will experiment with that. And of course all the other biohacking things like exercises, clean diet, other supplements like mineral vitamins are my friends from a long time ;)

    1. German tutor says:

      I am currently in a similar situation, travelling, can get only Niacin or Niacinamide, or B3 in yeast. So I also wonder how to at least get closer or implement it indirectly…. Any results in the meantime? :)

  13. Paul Bernitt says:

    I am a Board Certified Dr of Holistic Health and Director of an integrative health care clinic in Scottsdale, AZ. I have more than 25 years experience in the healthcare field focusing on early detection, prevention and reversal of lifestyle related diseases. I am most fulfilled by creating the value of optimal health and wellness. I have found that Maac10 brand NADH and NMN is very effective for oral dosing and cost effectiveness. I am also an advocate for a homeopathic called cell energy performance made by Professional Formulas to create more resonance for Krebs Cycle, ATP production, Coq10, glucose metabolism, Iron metabolism for increased oxygenation, NADH and NMN. Good stuff for maximum performance,

    1. Paul Bernitt says:

      Thank you for all your contributions to health, wellness and peak performance Ben!

  14. Jen says:

    Since NAD can help with addictions, I was wondering if it only works for drug/alcohol addictions or if it could help with other addictions such as food or shopping?


  15. sandra atherton says:

    please tell us a few good sources/brands of NAD+ Inhalation products. Sometimes Amazon doe not have all authentic products. It is hard to discern good brands from nor authentic brands.

  16. Sandra Chaska says:

    I just had my first IV drip of NAD+ and it was incredibly scarey. It was 3 vials of NAD+ formulated by an excellent compounding pharmacy in the USA. It was done in Ecuador where I reside part time, at my Doctors small clinic. The vials were brought here by a friend. It took 15 hours to drip 1000 ml saline with (3) 500 MG VIALS OF nad+…..I FELT LIKE MY HEART WAS SUPER CONSTRICTED, EVEN AT 1 DROP EVERY 2 SECONDS. after the drip finished ( 7.5 hours each day for 2 days)…..I had had many traumatic symptoms….hypothermia and shivers for over 2 hours ( only stopped by a far infrared heat biomat)…and low blood pressure of 114 over 54. During the drip my pressure was normal and so was the heart beat and blood oxygen. During the drip second day I had pain in intestines and loose stools. Of course there was the intense heart tightening and strange feeling of discomfort thru out the 15 hours. The protocol was given by my Doctor in the USA. I am not a sick person, I have intermittent tachycardia, and no other known diseases. I am only one one beta blocker, a baby dose of Concor 2.5mg. I am 68 and in otherwise good health. Has anyone else exhibited these symptoms? My USA Doctor said it was all in my attitude. Nice bedside manner….hmmm.

    1. Kathleen D Lieberman says:

      I believe it was too high of a dose. You should not have those feelings and they are easily altered by slowing the amount of NAD drips.

    2. Alyson says:

      That describes exactly what I experienced. I’m currently on my 5th IV treatment of 750 mgs. NAD and the drip has taken me anywhere from 3.5 hours on the first day to 6.5 on the 4th day, due to increasing discomfort in all the areas you described. Feels just horrible but I hope it’s worth it.

  17. Michael says:

    Ben ,

    I have been doing NAD + IVs on myself for almost 18 months. I too am a self proclaimed bio hacker . After listening to Dr Koniver and you talk I realized that I was already doing the NAD with quercitin combination and I can say empirically I have not gotten sick in the past year. No colds , flus, etc. I also manufacture my own NAD IVs . Very easy process once you have a reliable source. The vitamin c is also another easy IV to make. As a former paramedic I found that this route is the best . I do also take NAD sublingual and make that myself too . I recently finished up my masters in computer science and now am studying for my PhD . NAD has changed my life ! I now have just about every member of my family and friends taking NAD. I’m glad you have gotten the word out to people ! This is very important . I am planning a clinical trial in Chicago for addicts in 2019. We will be giving them NAD+ for free. If any of your listeners know anyone suffering please have them reply to this post .

    1. Brian Mantle says:


      My story sounds alot like yours. I have been experimenting with push IVs for the last 2 years and just starting to embark on the NAD IV. Can you email me please. Thank you! I tried through your website but no contact info came up.


      1. Michael Chase says:

        Brian ,

        Reach out at [email protected]

    2. I recommend posting this to the Kion Community. It’s a completely free online community of like-minded people who both have advice and are seeking advice.

      1. Michael Chase says:

        Thanks Ben !

    3. Nancy says:


      Please, get in touch.

      [email protected]

    4. Hey Michael, I’m stoked to here that you have benefited from NAD as well. It truly is life changing. After suffering from chronic lyme/Epstein Barre for 10+ years, NAD has given me a life that is now worth living. I definitely have interest in participating or promoting your trial in Chicago.
      I also have a few questions about your process for manufacturing your own NAD.
      Please reach out if you find the time.
      Thank you,
      Michael Radford

      [email protected]

    5. Wendy Gaines says:

      Interested in trail [email protected]

    6. Aileen Noll says:

      Hi Michael, would you mind sharing where you get your IV NAD? I’d like to also infuse myself but am having a difficult time finding a supplier.

    7. Stephen Zanca says:

      I am very interested in participating in your NAD
      clinical trial. I recently went through a 4 week inpatient detox for Suboxone and Valium. I then went to a partial hospitalization program and remained there for 2 months. I have relapsed on valium and Suboxone after 4 months of sobriety due to horrific PAWS symptoms. Any help would be greatly appreciated. Thanks, Stephen

      1. Stephen Zanca says:

        This is my contact info:
        [email protected]
        Thanks, Stephen

    8. bettina ahrendt says:

      Interested in trial
      Thank you

    9. Sander says:

      Hi Michael,

      I am living in The Netherlands, but I am personally as well as professionally interested in your clinical trial in Chicago. Anyway how we could connect?

      Best regards,


    10. Leonardo says:

      Hi there Michael! I’m from Brazil and I’m intriguing to know more about what you said. Are you taking NR or MNM for example as a NAD supplementation? How is possible to make it?

    11. Sunita Kaur says:

      Hey Michael,

      How often do you do the IV and it something that needs to be followed through or a one off NV In is enough? I’m based in London and its super expensive here!

    12. sam mandrozos says:

      i am suffering from benzo addiction for 13 years at a high dosage can you please help me out?

    13. Glude says:

      Does anyone knows and can recommend me of a good source/compound pharmacy from where I can get NAD+ ?

      Thanks in advanced.

    14. Rob says:

      What are your thought on NR?

    15. Richard says:

      Can I ask you to clarify what the supply chain looks like for making your own IV’s? Is NAD available already in solutions via compounding pharmacies or do you have to deliver the base solution to a compounding pharmacy?

      Thank you for the information as, to be candid, I find the cost associated with these IV treatments repulsive given the cost of the base substance. This isn’t rocket science and people of all financial statues should have a right to good health.

      I am looking to make in roads in this space but need to do more research on how to secure the appropriate supply chain. If you have any advice, please let me know.

    16. Jeremy says:

      Hi Michael, this post is 7 months old now, but I would love to connect with you regarding the work you’re doing with NAD and addicts. Tried your website but it appears to be down.

    17. Has your conference for 2019 passed already? I’d be interested in coming out to Chicago from NJ.

    18. Stian van Zweden says:

      Michael do you have somewhere i can contact you? Would like to ask you some questions? @Health pac on IG and just name on FB

    19. Kimberly Clark says:

      Hi Michael,

      I’ve done the NAD IV and sub q. Also high levels of Vitamin C. I love the effects but it can get very expensive. Would you be willing to share where you get your NAD and C to make your own IVs?

      Thank you,

  18. Nile Reinartz says:

    Product Discussion.

    Between these 2 products which one would be a better purchase if you were only going to buy 1.


    -What I’m looking for, stacking myitocondra, ATP, NAD+ and healthy cell production.

    -I intermittent fast.

    -Training high intensity 5days a week.

    Thorne – ResveraCel


    TRU Niagen

    Please help..

    1. Trevor says:

      Thorne resveracel I think. Its got a solid basis of cell function boosters/protectants: trans-resveratrol, nicotinamide riboside (most effective NAD+ precursor without actually getting IV NAD+), quarcetine, & betain for methylation support.

  19. Hooe says:

    I am diagnosed with PLS, a Motor Neuron Disease on the ALS spectrum. I have getting IV NAD for 2 months in varying dosages from 500 – 1500 mg. It is mixed saline solution and an accompanying bag of saline is dropped from another bag to reduce discomfort. When I leave the drs office I am very stiff and it usually subsides after a day or two. However in the last I am experiencing swollen feet and ankles and a lot of joint pain and tight muscles. Wondering what be the cause and guessing too much saline over time?

  20. Dre says:

    The guest mentioned how NAD levels are negatively impacted by sun and oxygen. Does this mean we need to measure NAD to properly dose our infrared sauna and oxygen therapies?

  21. rene espinoza says:

    would like some resources on buying NAD+ for self administration cant afford the costs of treetment my girlfriend is a RN thank you

    1. I will reveal my source very soon. Stay tuned by signing up for my newsletter.

      1. Gary Hendricks says:

        Please send more information on a way to begin this therapy. Thank you

      2. Zack McCoy says:

        Can you please send me a link or a message of some good NAD sources to buy? I have someone to administer it to me. Thanks


    2. Sarah says:

      Me TOO!!! I am a Nurse Practitioner looking for this as well. I already administer myself IV drips of Vitamin C, glutathione, and multivitamins. If anyone has a resource, please share.

      1. Steven says:

        Olympia Pharmacy

  22. Dan says:

    What is the single best oral option to get increased NAD? And What would a good cocktail be?

      1. Chris M says:

        Hi Ben,

        What is your opinion of this liquid oral supplement:

        Absonutrix NAD Power Booster | 4 oz Big Bottle 120 Days Supply | Nicotinamide Riboside and Pterostilbene Daily Supplement| NAD Supplement | Improved Cell Repair | NAD+

        Your thoughts greatly appreciated.

        1. Can't say, I haven't tried that one.

  23. Clyde Boyer says:

    I’m afraid I’m a little confused. Does high-dosage Niacin negatively impact the possible benefits of oral NAD+ supplements? It appears that Niacin can inhibit sirtuin function. I currently take high dosage niacin and NAD+ supplements.

  24. marion says:

    dear ben:

    I do not have a microphone.

    I prefer typing. I want to know where and how nad can be purchased.

    I want to know how much.

    obviously, there is a technique to administering nad.

    do you demonstrate how it is done.

    respectfully waiting for your reply:


    1. Marion, I will have a podcast on this in the future. You can sign up to be notified if you're not already.

  25. Mike says:

    Hey Ben,

    I recently listened to a Podcast with another NAD “expert.” I found out later that he was the owner of one of the Nicotinamide Ribosome (NR) pill companies. Obviously he was toting the benefits of oral ingestion of the precursor to NAD. His claim was that the body can’t use intravenous NAD because it has to break it down into NR to convert it back into NAD that the body uses. He claims that the oral NR is 15 times more bioavaialable than the IV NAD. Is there truth to that statement? I see you recently commented that you will be having a podcast talking about NAD. Can you talk about the differences between NR and NAD, bioavailability, what is better?

    1. Stay tuned, I have a podcast coming out about this soon.

    2. Jay shelley says:

      Is NR preferable to supplementing with NAD or NADH, or vice versa. Why?


      1. Dr. Brenner and I went over that in this podcast <a href="http:// :” target=”_blank”> <a href="http://:” target=”_blank”>:

    3. Ashley says:

      I just listened to that episode and thought the same thing!! Thanks for asking that, Mike!

    4. Mitochondria patient says:

      I have taken high doses of NR, which did nothing for me. The Enada NADH product helped enough to get me through a work out in the gym.

      My doctor gave me an IV of NAD+, which gave me increased energy for 36 hours. I also take the LIAS Research NAD+ product daily, which has dramatically increased my qualuty of life.

      The NR people are very aggressive about saying NAD+ doesn’t work, but my very real experience says it does, and I’m willing to pay for a product that works.

      From what I’ve been able to find, there are 4 parhways for getting NAD+ levels up. Perhaps these pathways do not work the same in every one. At any rate NR has no value for me and I’ve spent a fair amount of money trying it.

    5. Hope says:

      I have the same question. Is oral NR more bioavailable than NAD IV?

      Sent from my iPhone

    6. Joe says:

      Mike, there are such claims made for subliminally delivered NMN. The thought is too much of NNM or the other major precursor, NR, does not make it out of the GI tract and into the blood stream.

  26. Joshua Polin says:

    Hey Ben, hope everything is going well. i was wondering where you purchased your NDA for self injections. Thanks for your time man, have a nice one.

    1. john kelly says:

      same here

      1. Andrew Marshall says:

        same here

    2. Michael says:

      Me too.

    3. Stay tuned, I'll be talking about this in an upcoming podcast!

      1. Jason says:

        Is that podcast here yet?

  27. Eileen says:

    Hello Ben,

    Could you help me possibly?

    I have been reading up on NAD+ and NADH. I have not found one aritlce that compares the benefits

    in the body so I do not know which form to take. I know the NAD+ is produced by B3 and that is how

    it is sold as opposed to the NADH which is sold as it, enteric coated or sublingual.

    But which should I take?

    I have Asperger and I am already 68 and I never feel well.

    I hope you get this.

    Thank you very much.

  28. Paul says:

    Dr mercola mentions mixing niacin and d robise and say this is like niagen?

  29. SG says:

    Has any SPECT scans been done before and after IV NAD+ Therapy?

    1. There has to be. Amen Clinic psychiatrist, Dr Elizabeth Stuller spoke at a prior NAD summit.

      Check this out:

      This is considered to be one of the most powerful testing equipment available today. It’s a 7 tesla FMRI machine. Many get MRIs done on their brains for things like multiple sclerosis. This one is powerful it can detect atoms. Rumor has it that the same machine in Minnesota has been measuring NAD levels in the brain after NAD, NMN and NR administration. The work may soon be published if it isn’t public already. I heard that IV NAD raises NAD levels in the brain! Same with NMN. But not with NR!

  30. The NAD Treatment Center is the official organizer for the NAD Summit in 2018 in San Diego. The heads in the industry will be there. It’s a conference for medical doctors, naturapaths and other clinicians as well as scientists in the research on NAD and NAD IV.

  31. Joe Maushart says:

    Hey Ben,

    I am looking for a NAD Nicotinamide Adenine Dinucleotide IV treatment in the San Francisco bay area. Do you know anyone you could help connect me with?

    1. I don't, but these sites are a good start for your search…

      1. Joe says:

        Thank you sir! I got in touch with Tom today and am going to make moves get the treatment done in SD. :) Ibogaine proved to not be answer I thought it was for opioid dependence, but I think NAD might be.

        1. Seasidekitty says:

          Joe, did you do the treatment, how did it go? Email me please [email protected]


    2. Chris Collins says:

      Contact Dr. Robert Rowen in Santa Rosa. His office can administer the NAD.

    3. Jean says:

      Did you find an NAdh IV in Bay Area or SF, can’t find a center online.

    4. Katya says:


      Looking for the one in SF as well. Where you able to find a good place?


  32. Jerry says:

    Hi Ben, if taking Pau D’Arco tea with fats on a daily basis, then is further supplementation needed? (i.e. supplements like

    Thorne ResveraCel, Nicotinamide Riboside (Niagen) with Resveratrol and Cofactors). Other than IV treatments, what’s the best way to flush the system with NADs? I take it that supplementation is useful for NAD maintenance rather than getting the initial flush of NADs needed.

    1. It totally depends on the supplements. I wouldn't see a need for a huge amount of additional mitochondrial support unless you are really beating yourself up with exercise and stress. However I would still add in a good multivitamin and a good fish oil.

    2. Mark says:

      Was Pau D’Arco tea mentioned ? I must have missed it

  33. Sherri says:

    I really enjoyed your podcast! So informative! I am preparing to undergo IV NAD treatment next month in Scottsdale with Dr. Ron Peters. Do you know if there are risks for someone with a compromised liver? I’m very mercury toxic as well and a little bit afraid that the positive effects of the NAD will somehow result in a lot of mercury coming out of the liver and other tissues and possibly overwhelming my system. (I had this kind of experience after one IV of phosphatidylcholine several months ago, with increased brain fog and fatigue and huge strain on my adrenals.) I was also wondering if having a liver that works well is needed for the conversion of all of these molecules. (Niacin, NMN, NR, NAD, etc.) Furthermore, is there any kind of contraindication at all with NAD?

    I do have late stage Lyme disease and feel like this is my last hope. Nothing is working in my body and hasn’t for several years. Thank you in advance. And any other advice you might give to someone preparing to undergo this treatment in the next 3 to 4 weeks would be greatly appreciated. Dr. Peters recommended I do coffee enemas. But to be honest I’m very weak and not sure if I can even handle those. He suggested I start with a small amount, but just the whole idea scares me, being as I am probably more toxic than 99% of the world. (Lived in mold for years, bad yeast overgrowth, years of taking prescription medications including opioids, etc.)

    Last question, should the caloric restriction/fasting be done during the IV NAD treatment or after? Thank you very much in advance!


    1. I've seen zero evidence of mercury toxicity risks. But caloric restriction and fasting will indeed enhance effects! Ask your practitioner about any supplement contraindications. I am not a doctor and this is not to be taken, interpreted or construed as medical advice. Please talk with a licensed medical professional about this. These are just my own personal thoughts and not a prescription or a diagnosis or any form of health care whatsoever.

    2. Thomas Shepard says:

      for Sherri, and her post 9/23/17:

      Tim Ferriss had Lyme and he might be your best resource. I would scour the web with his name and Lyme for help. He is extremely busy but you might reach out to him on twitter @tferriss

      1. TJ Nelson says:

        I have Lyme and am slowly getting better and have felt better than I have in 1.5 years now. Tim Ferriss seems like he had a mild case of Lyme with no coinfections, which he doesn’t mention much other than a ketogenic diet, gut health, and how he tried doxycycline.

        A lot of people refer to Tim Ferriss because they know of him, but he is not the best resource for Lyme. Especially since most people these days have other coinfections like babesia, bartonella, RMSF, etc.

    3. David says:

      Hello Sherri,

      I have been considering the NAD iv treatment for addiction and depression. I am a Scottsdale resident and was wondering if you went through with the treatment, and if so where in Scottsdale did you go? Would love to hear your thoughts and opinion on NAD after going through with it.



  34. Elizabeth says:

    Has NAD been tried yet to treat COPD? I have COPD, have never smoked, but have had numerous pneumonias, including fungal infections, so there is a lot of scar tissue. I currently use oxygen for sleep and for exercise, and I can tell that my strength and endurance have decreased in the past few months.

  35. Jack Black says:

    These NAD IV clinics in the USA are all part of the William Hitt clan. William Hitt was a Quack and a fraud. Contact Attorney Jenelle C Prins for more information on him. I’d stay far away from these NAD IV clinics.

    “California attorney Jenelle C Prins, who has investigated Hitt, reports that “William Hitt does not have any undergraduate or medical degrees. In 1987 he was sued by the State of Texas, Case No 87 27882, for fraudulent practices. In sworn documents filed with the court, he admitted that he had no degrees of any type (except for one from what Hitt called ‘a paper mill’, known as Walden College).” Prins reports that the University of Colorado, where Hitt once claimed to have been awarded an MD in 1952, “has no record of him”.

    And what of that Nobel Prize? Hitt claims to have won the Nobel Peace Prize while a member of the International Physicians for the Prevention of Nuclear War. This is false, she says.

    The International Physicians for the Prevention of Nuclear War corresponded with me and stated that Hitt had never been a member. Hitt has recently changed his story to say he was a member of the Mexican delegation to the International Physicians et al, but I checked this claim as well and it is also false.”

    Hitt claims to have won a “prestigious Eli Lily Award and several other awards. “I called Eli Lily and spoke with a woman there who researched Hitt’s claim,” says Prins. “First, Eli Lilly does not give out a prize. They do, however, provide grants, but no grant was ever awarded to Hitt.”

    “We learnt of his falsity when one of my clients returned from treatment for Hepatitis C in Mexico,” says Prins. “When she went to her regular doctor to check her viral load, her levels were higher than when she went to Mexico.” Prins says that in this and several other cases, “Hitt doctored test results”…”

    The James Randi Educational Foundation

    1. Jack Black says:

      The South African’s and Dr. Abram Hoffer were the ones who started NAD therapy. You can download a NAD therapy Manual from this website…

    2. Jennifer Hartranft says:

      John Edward Humiston MD has inherited Hitt’s practice and moved it to The Center For Health And Well being in San Diego, CA. At the invitation of Janette Gray, MD. He operates The NeuroRecover IV Clinic.

      He has Narcissistic Personality Disorder. I terminated my MD/patient relationship with him. He is a complete fraud. His medical practices are questionable. Ineffective and costly.

      I am fortunate that I was not permanently harmed.

      1. Jordan says:

        His Nerorecover is cheaper than the NAD treatment center. The NAD treatment center is the most expensive around at 1350 a day… Neeorecover is 950 a day and you get nad plus amino acids..

    3. Jenelle C. Prins says:

      Jack, thanks for passing this information along. Not a single degree, award, or accolade that Hitt claimed was true. He fabricated his entire background. It was proven over and over that the “treatments” he advocated and/or provided were fraudulent and clinically ineffective. It is possible that some people found relief through the placebo effect, but it was not due to anything Hitt claimed to be doing. Anyone who continued Hitt’s so-called medical practice was simply continuing a very elaborate and very fraudulent con created by Hitt.

  36. Anne C Murphy says:

    I can attest that NAD/niagen oral supplementation @ 1,000mg a day, combined with pterostibine and A catalyst (I’d name but the FCC would kill me), was probably the most game changing for me over the past five years. I do see how it fixes dopamine imbalances, increases stamina and serves as an overall regenerator. For anybody who has ever struggled with chronic fatigue, Lyme etc., it also appears to give a mitochondrial regenerative boost that is sorely needed in those I’ve recommended to. I’m not sold on IVs. 20,000 dollars is ludacris. I’ve seen the studies with oral supplementation and I’m convinced if it does not work at the 250 dose, to go up to the 1 g. I’m on a high dose again recovering from a concussion, love the recovery time and am sold. Best content on the Internet as usual too, BG (Murph)

    1. Jack Black says:


      Truthfully I think these NAD IV therapy clinics should be shut down. For one they say they are in brain restoration and charge $1000-1300 a day but they do NOT even measure NAD or neurotransmitter levels before or after treatment. They are just ripping off affluent families with junkies at this point. Sure a junkie will say he feels better after 10 days of treatment but what are his ACTUAL NAD or Neurotransmitter levels post treatment? Until these clinics start doing clinical trials showing actual DATA I’d stay away from them. Yes they MIGHT help but charging $1300 a day for what $75-100 at most for supplements is ridicules.

      1. Jordan says:

        There’s is a Dr in Utah that charges 4500 for ten days. You just gotta shop around. Personally I feel like you shouldn’t knock something you have never tried. How can it helps sooo many people if it’s baloney?

        1. Jon says:

          Jordan can you recommend the Dr in Utah? looking for a good starting point to research. Thank you

          1. Jordan says:

            Forget it John, they literally just changed their prices.i was really upset and let them hear about it. So now they are charging 10,000 for ten days.still cheaper than the nad treatment center and they do give you a bit more stuff for the money BUT the nad treatment center has been really responsive and i really appreciate that. I know with them i can start any day of the week and they get back to me and work with me.. it took like a week for both the place in utah which is dr haskell if you still want to check it out and even longer than a week for the center of health and wellbeing in san siego. Totally rude, when an addict wants to get clean you contact the right away, not wait a week…and you certainly dont go changing your prices so drastically.. ughhh good luck!

          2. Alexander Haskell says:

            Haskell here… the doc in Utah. We changed our prices only because we were seeing some good results with just doing the NAD intravenously, but people obviously have many other issues with their health that the NAD was not helping with, so I feel it’s really important to address these underlying biochemical, hormonal and genetic issues and to not think that IV NAD is a cure all. These issues must be addressed: nutritional deficiencies, other chemical residues including pharmaceuticals which add to the body’s total burden, and silent chronic low-grade infections. So I decided not to offer IV NAD as a stand alone, so this new price of $10,000 includes the 10 NAD IVs, all labs (blood, urine, saliva and genetic cheek swab, the dark-field microscope to see if there are pathogens, all our other nutritional IVs (vitamins, minerals, BiOcean, alpha lipoic acid, etc.), all our oxidative IVs (10-pass Zotzmann ozone, UBI and UVLRx), and all our purification therapies (saunas, colon hydrotherapy and lymphatic drainage hydrotherapy). Also all the consults with me, my nutritionist and my daughter who deals with the psychology part. During the 10 days of NAD we have fresh organic snacks and juices. If you want to call our clinic we can forward my ebook which goes over all the above details (801.875.9292). By the way I spent 2 days at Hitt’s clinic years ago and spoke with many of his clients who felt Hitt’s protocol had saved their life, and he was a very genuine, humble man.

    2. Rodney Bridges says:

      Anne can you give us a hint what the catalyst you use is?

    3. Jordan says:

      You cant even give us the full directions in yoir comment? You think the FCC is following your every move or what? Its hard to give any merit to what you are saying…

    4. Sue says:

      Are you mold CIRS sick? Seems it may push over worked Imine system and cause any excess stress? We’re yiu very sensitive? Insomnia type

  37. This podcast was the 1st I’ve listened to that actually answered the exact questions I had, and presented clear answers that guided my decisions. I’ve begun taking Niacel based on getting the information I was seeking. I appreciate the presentation of cutting edge research translated into user friendly, specific information. The overall discussion helped me understand and distinguish the reasons for and against choosing the products. I come from an all medical family, including 2 of my own sons who are physicians. I am the one the family depends on for supplement and cutting age research, and this podcast gave me confidence in my recommendation to my family of NAD.

  38. Mary Jean Flood says:

    My husband has been diagnosed with Parkinson’s disease. He is and has always been into physical fitness. We want to protect his cognitive functions.What brand of NAD is the best or would you suggest a NAD treatment center for I V NAD near Louisville Kentucky.

    1. Hi Mary Jean, I would suggest you have a listen to the podcast above and then check out the resources section for the brands I recommend as they are all in there. Hope that helps!

    2. NAD is not FDA approved for the treatment of Parkinson’s, but we have seen some promising results. Usually patients get some reduction in symptoms. Please check out this testimonial.

  39. Olwen McNeill says:


    I am contacting you for my 72 year old father, he was diagnosed with Parkinson’s just over two years ago now. Before this he was incredibly fit and healthy.

    I want to know if this treatment can help with a condition like this?

    1. Contact Tom via his website above. He will fill you in. He has some very good ideas about Parkinson's for sure. I am not a doctor and this is not to be taken, interpreted or construed as medical advice. Please talk with a licensed medical professional about this. These are just my own personal thoughts and not a prescription or a diagnosis or any form of health care whatsoever.

  40. Jonathan says:

    Hi Guys,

    Great show, while listening to the information about NAD and how it helps with oxidative stress, I wonder if this would be helpful to someone with Cystic Fibrosis, as the lungs are constantly being damaged and this may help?

  41. christian j pasquariello says:

    I wouldn’t discount oral NAD either. I used Jarrow’s NAD for three days and was able to cut my opiate intake in half during those three days with ZERO consequences, and I’m talking a long acting opiate not a short acting one, the long being much tougher to taper/quit. I’m now taking half of what I was and am trying to figure out if I should stop the NAD for a week, then blast it again or keep taking it daily?

  42. solomon bashi says:

    Is there a difference between Nicotinamide Mononucleotide (NMN) and Nicotinamide such as in the below link:….

  43. dana mcdonald says:

    my son is 32 and 6 yrs ago doctors got him on benzos for anxiety which started in early childhood….with no warnings of what was to come….he now struggles with extreme anxiety and depression…we are looking for something to literally save his life….will NAD help…

    1. Hmm…for anxiety CBD might be more up your alley. Check this out:…

    2. Sam says:

      Did you try NAD+. It’s a couple of years on now. I have had success using Niacel 250 as the basis for treating anxiety. I support the mitochondria with ubiquinol, PQQ and liposomal B12 too. I also use restore4life Restore against glyphosate damage to the biome and intestinal barrier. Check out Zak Bush.
      Tell me how your son is now

  44. steph says:

    Brand new research on human trials says oral worked well… which is in direct conflict to what the guy on this podcast kept saying…

    “Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner’s lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses.” “This trial shows that oral NR safely boosts human NAD+ metabolism,”……

  45. george stanko says:

    Does NAD HELP WITH Dimentia?

  46. Lana Fatima Djagaeva says:


    I’m holistic RN and just been expose to NAD info and it fascinates me.

    How can I get trained and help people that so much in physical and emotional pain.

    I’m all about alternatives.


  47. Kate says:

    If we live in Sydney can we somehow volunteer to be involved in dr grants trials?

    1. You best contact him directly about this one!

      1. Skip Pascasio says:


        I’m at the right now. It’s my second day. I’m here for mental clarity. I have been taking prescribed Adderrall for the last 5 years and my focus deteriorated over the years due to inconsistent generic Adderall. Blue Cross sent me a letter stating that they would pay for name brand Adderall because they were noticing problems with their insured members. I decided to stop that poison all together. NAD_+ is the real deal. My focus has already returned, but I’m going to stay two more days to solidify my gains. I met you at the 1st bulletproof conference and I am the guy that Ted Harty mentioned regarding Wim Hof in your podcast on freediving. I was trained my him a couple of years ago. You are killing it with your latest podcasts. Keep up the good work. If you will be at the BP conference in Pasadena next month I hope I get to say thanks. You and Dave are helping millions. Cheers. PS. For your audience. Keto-salts blow adderall away. Can’t wait for keto-esters to hit the market. Please let me know when they do. I’m sure you’re on top of that subject. Thanks again!!

  48. Craig says:

    Very interesting.

    Coupla questions.

    Just outta curiosity, what sort of dosages are being administered intravenously?

    Did I hear right that they were a 7hr drip?

    It was mentioned how one person hospitalised himself. Where there any specifics on how he did this?

    1. Hope says:

      I would also like to know the answer to the question about what kinds of dosages are being used and how frequently. I have been receiving 500 mg to 1500 mg 3xweek for about 2 months. I have PLS so nerve cell regeneration is very slow.

  49. Roni says:

    I wanted to know if anyone has every used the NAD to treat severe concussions?

    1. Yes, Springfield Wellness Clinic (who we consult with) has had some experience with concussions. Paraphrasing Springfield: “We have certainly had a few patients with concussions. We had a patient with nine concussions. He had considerable damage to his eyes (detached retina). He had a tremendous response from the IV NAD. We also have had an NFL football player get success.”…

  50. René Pothetes says:

    A GREAT podcast Ben. I love the quality of guest and information you continue to share.

    Based on the 500-1000mg daily recommended dose of NAD Riboside – which brand are you going to try ?

    1. Probably Niacell but stay tuned.. <a href="http:// .” target=”_blank”> <a href="http://.” target=”_blank”>.

      1. imoseyon says:

        That’s exactly what i ordered after listening to your podcast. :)

  51. Jennifer Ortiz says:

    Thanks for the information. How does this all tie into your discussions about large does niacin/sauna protocol for detox?

    1. Different effect between niacin and NAD. I'd still use the protocol at for the sauna stuff…

  52. Leila Fahim says:

    Hi Ben

    Thanks for the great podcast!

    What do you recommend for skin reaction, flushing, and tingling from Vit B3 Supp other than taking it with food?

  53. Phil Krueger says:

    Hi Ben, Great podcast!!! I am interested in the supplement therapy. Are there any guidelines that would help align us to right dosages or caveats that tell us we are taking too much?

    Thank you,
    Phil Krueger

  54. gina says:

    I know there are products on the market, for example Elysium, but I thought they said it doesn’t work taken internally, except by IV or shot? Did I understand that incorrectly?

  55. Brent says:

    I want to hear more on MTHFR ( have the gene thats means i need more Methylated B Vitamins ) and NAD
    he started to talk about it and then went on to something else.

  56. Pam says:

    Would this product be good for chronic insomnia?

    1. Again, research needs to be done.

      We see that sleep patterns get reset in clinical practice with NAD+ IV administration. Definitely. We personally have had an improvement in sleep with NAD therapy at the NAD Treatment Center (

      On a theoretical level, Dr. Ross Grant thinks that sleep cycles are connected to NAD levels as well. For a heavier explanation, he cited the following: “In the suprachiasmatic nucleus, biological rhythms are maintained by a central clock of around 20,000 pacemaker neurons.¹ These neurons can degenerate with age and oxidative stress. NAMPT/NAD drives the circadian clock feedback cycle through SIRT1 and Clock:BMAL1². As the NAD levels oscillate over the circadian cycle the activity of SIRT1 oscillates linking the metabolic state of the cell through an epigenetic mechanism to the circadian clock.¹”

      In other words, NAD might be epigenetically running our internal clock.

      1. Nature Reviews Neuroscience 14, 69-75 (January 2013)…

      2. Biochimica et Biophysica Acta [2010, 1804(8):1584-1590]

      There are over 100 cited causes of insomnia. It seems that NAD administration is extremely effective in many of these causation so, and less effective in others; for example in some psychiatric states.

      But someone ought to do a study on NAD levels in that part in the brain before and after NAD administration. There are over 100 cited causes of insomnia. It seems that NAD administration is extremely effective in many of these causation so, and less effective in others; for example in some psychiatric states.

  57. John gillen says:

    Well done Ben great work regards to Ross if you talking to him as your comments continue to grow thought I would let you know I have been treating clients with intravenous NAD+ in London for over 4 yrs at or best regards. John Gillen Director.

    1. Sandra Chaska says:

      the first two 7.5 hour drips were a nightmare. It was 3 vials of NAD+ formulated by an excellent compounding pharmacy in the USA. It was done in Ecuador where I reside part time, at my Doctors small clinic. The vials were brought here by a friend. It took 15 hours to drip 1000 ml saline with (3) 500 MG VIALS OF nad+…..I FELT LIKE MY HEART WAS SUPER CONSTRICTED, EVEN AT 1 DROP EVERY 2 SECONDS. after the drip finished ( 7.5 hours each day for 2 days)…..I had many traumatic symptoms….hypothermia and shivers for over 2 hours ( only stopped by a far infrared heat biomat)…and low blood pressure of 114 over 54. During the drip my pressure was normal and so was the heart beat and blood oxygen. During the drip second day I had pain in intestines and loose stools. Of course there was the intense heart tightening and strange feeling of discomfort thru out the 15 hours. The protocol was given by my Doctor in the USA. I am not a sick person, I have intermittent tachycardia, and no other known diseases. I am only one one beta blocker, a baby dose of Concor 2.5mg. I had been taking NAD+ sublinguals for 3 weeks and NMN for 2 months before starting the drips. I am 68 and in otherwise good health. Has anyone else exhibited these symptoms? My USA Doctor said it was all in my attitude. Nice bedside manner….hmmm.

  58. Jill Baillio says:

    Great podcast! I’ve been wanting to try Nicotinamide Riboside for a while but have some MTHFR mutations that give me pause. Would supplementing with Nicotinamide Riboside have an adverse impact on methylation? My (possibly uninformed) understanding is that Niacin reduces methylation. For people who are undermethylators would this be a problem or is this different enough from Niacin not to be so?

  59. Todd G Holubitsky says:

    Great podcast as usual. What about the intra nasal form?

    1. Contact or 844-NAD-PLUS for further details.

  60. gina says:

    Ben correct me if I’m wrong but the Thorne Niasafe is not the form of NAD that’s recommended for home use/

    1. No it is not. That would be resveracell. Niasafe would be for niacin/sauna hack I talk about at

  61. DANIEL L SHEEHAN says:

    Check out Elysium Basis at

    Nicotinamide Riboside and Pterostilbene supplement.

    My experience (n=1) is positive after 4 months.

  62. Alistair says:

    Ben, another great podcast. Your recent podcasts have all been interesting and it seems they’ve been building on each other, with cross overs here and there and this one was just, well, stunningly informative. Ever since I’ve read so much about this stuff to gain further understanding and something jumped out at me…….since you are very open with your blood results and tests, your recent cortisol podcast for example……thought I’d run this past you……

    You’ve said that you have high cortisol and had various other markers tested to try to pin down what may be the cause. One of the hacks you do is infra red sauna and high dose niacin. It was noted on the podcast by one of your guests that niacin is a precursor to NAD but too much of it can block sirt 1, so inhibiting the effects of NAD…not the desired outcome. I’ve read that high dose niacin can also lead to insulin resistance, notably in the liver and to liver dysfunction. You’ve commented that you have a genetic predisposition potentially to diabetes and on your cortisol podcast your guest analysing some of your bio markers suggested possibly a problem in your liver for further investigation. I’m only putting this to you as you’ve shared so much of your blood work with listeners that it appears I have access to your medical records! You no doubt will be aware of this but maybe not and thought it may be a useful experiment for you to try……..quit the high dose niacin and re-test possibly? Possibly not, too, I know. I’ve overdosed on your podcasts recently and geeked out too much maybe? But maybe there is a link? Anyway, looking forward to your next show……cheers

    1. Yes, I will be retesting, etc. Stay tuned!

  63. Tammy Trew says:

    Hi Ben- fellow Washingtonian (:

    I just wanted to tell you that this has to be one of my most favorite and informative podcasts that I have heard from you so far! I cannot thank you enough for this information. I have recently been reading about NAD+ and have been curious but to hear about it from two amazing experts and then the testimonial from someone who has improved their health greatly from it was incredibly interesting and makes me hopeful. I have been suffering from chronic fatigue for a while now, my sister has fibromyalgia and ankelosing spondylitis for which she has been taking pain medicine (opioids) for quite a long time. Both of us also suffer from MTHFR so this podcast was very interesting for both of us. Will be keeping an eye out to see if anyone up here is doing this intravenously!

    1. In our opinion, NAD therapy is extremely efficacious for those who take opiates. We shot this video yesterday. This patient was a listener of Ben Greenfield’s podcast and has just finished treatment of NAD therapy for opiate use. We see tremendous responses with fibromyalgia and chronic fatigue. Feel free to contact the NAD treatment center ( for more details. He is so satisfied with the results, that he is willing to talk to others about his experience.

  64. Greg says:

    Thank you Ben, and your guests, for another thought provoking podcast. It was mentioned the nicotinamide on its own is dose dependent, too much can inhibit certain pathways but the right dosage increases NAD. The better oral supp being the riboside variant. If looking to increase NAD+ without nicotinamide supps another precursor that was mentioned is vitamin B3. So could high doses of vitamin B3 in food or as a supp achieve the same thing… stimulate a natural production of NAD+, in otherwise healthy people? High dose IV NAD+ is recommended to swamp the body for people with ill health but in healthy people, not necessary, maybe? Or is vitamin B3 too dose dependent, too much causing inhibition of similar pathways that nicotinamide interrupts? Looking forward to your next podcast………thank you

  65. Miles Pelton says:

    Has research on NAD evaluated the reaction on persons afflicted with Fluoroquinolone Toxicity (adverse reaction to fluoroquinolone antibiotics)?

    1. Tom Ingoglia says:

      To date there is no published research on IV NAD therapy and fluoroquinolone toxicity, an adverse reaction to synthetic antibiotics called fluoroquinolones (eg. cipro, levequin). And some have theorized that FQ toxicity is linked to mitochondrial dysfunction. However, the NAD Treatment Center has treated patients with fluoroquinolone toxicity. Hear Case Mandel’s road to recovery from fluoroquinolone toxicity.

  66. Jon says:

    Ben, great podcast. Do your guests have any thoughts about oxaloacetate? Dave Asprey promotes it. I think it also goes by the name of BenaGene.

    1. Joe says:

      I was wondering about this as well.

    2. Devon says:

      Yes, it is a patented supplement. You can buy it as benaGene (capsules) or KetoPrime (lozenges).

  67. Mike says:

    I’m still a little confused about the difference between Nicotinamide, Nicotinamide Riboside, NAD, NAD+, etc. Is it all the same thing?

    1. Tom Ingoglia says:


      Nicotinamide and nicotinamide riboside (NR) are both precursors to NAD, as well as nicotinic acid and tryptophan. There are various reasons why the metabolic pathway for tryptophan to NAD is inferior.

      NAD is the same thing as NAD+. Also, NADH is the reduced form of NAD. That is, it’s the used up version. The different forms of NAD mentioned are metabolized and absorbed differently through the digestive system.

      Nicotinamide riboside seems to be the most bioavailable form through the small intestine, but this process isn’t 100% efficient. Plus, supplementation of NR does not have a long history of decades like NAD+ but has a lot of recent human studies. There is also a major issue relating to the salvage pathway of NR. This can limit not only sirtuins produced. The problem with NR is that it lacks the adenine and the dinucleotide. People still feel the response of NR (for example, greater energy or depression relief).

      NAD treatment Center feels, intravenous NAD is far superior. IV NAD by-passes the digestive process by administering the NAD straight into the circulatory system. This allows the NAD to reach the cells directly and promptly. Plus, the dose in the IV is much higher. True, NAD lacks some human research, but there have been tens of thousands of people that have done NAD IV therapy because it does not need FDA approval since it is a natural vitamin.

      Finally, the clinic thinks the responses many people have from NAD is just so much more positive. People report long-term (years) positive benefit: physical energy, daily mental energy, anxiety, depression, drug craving help, pain minimization among others.

      See for yourself:…

  68. Derek says:

    So the supplements mentioned in the episode are Nicotinamide and Nicotinamide Riboside… but if I go to amazon or iherb and search for “nicotinamide adenine dinucleotide”, there are products that contain just Panmol, which is:

    “NADH (Reduced Nicotinamide Adenine Dinucleotide), is the metabolically active form of Vitamin B3, also known as Niacin. NADH is essential for the production of cellular energy (ATP) from glucose and fat. Therefore, the more NADH a cell has available, the more energy it has available to operate with optimal efficiency. NADH is also directly involved in neurotransmitter production, the maintenance of genetic integrity, and the support of proper immune system function. Although NADH is normally unstable outside of the body, Panmol NADH uses a patented process to naturally preserve its effectiveness, thereby delivering stable and bioavailable NADH to the body.”

    Any thoughts on this type of supplement vs the two Nicotinamides mentioned in the podcast?

    1. NAD can be supplemented through several products. Be careful because there are differences between claims and products. NAD levels can be increased with Nicotinamide Riboside and is generally poorly absorbed with oral NAD. NAD is available in a high quality product through a pharmacy in Louisiana via an intranasal spray, and an oral NAD preparation. You require a doctor’s prescription. Dr. Milgram, from The NAD Treatment Center can usually authorize this product for those who request it, after answering a few questions. It is apparent that, in most cases, just oral or intranasal supplementation is inadequate to restore initial depleted NAD levels. Patients generally have had significant improvement only after an initial flooding with NAD by intravenous administration, followed by oral or intranasal therapy with known high quality NAD supplement. These are protocols provided by only a few clinics in the USA. Be careful not to use NADH, and there are products which provide very little NAD through the oral route.

  69. James says:

    So how does Elysium’s supplement rank as far as these NAD supplements go?

  70. Derek says:

    Great podcast!

    But a bit complex for laypeople… do you have a few bullet points on how-to-supplement-NAD-for-dummies?

    1. We actually discuss this during the episode in terms of dosage, etc. for the supplements I have listed in the resources, but Thomas may have more tips….

      1. James says:

        Thanks for the podcast, Ben. Have you seen Thorne Research new NAD supplement? I am wondering if there is any promise to it.

        1. quite possibly…I'm looking into it so stay tuned!

    2. Jared says:

      I was wondering the same thing it would be cool to have the details of the dosage info side noted I got confused between the two types and then considers I might have to listen all over again and or scroll around to figure those details

  71. Linda says:

    What is the Dr.’s name in Louisana regarding NAD – NMN? Can’t figure out how to spell it to look it up.

    1. Dr. Richard Mestayer’s clinic is located in Louisiana. Their website is: .

      Thanks to his wife, Paula Norris Mestayer, a psychotherapist, Springfield Wellness Center has the longest running clinic providing NAD in the USA. Paula is the pioneer that helped introduce NAD to America in 2001. About 1,000 patients have come through their doors. The NAD Treatment Center ( works with Dr. Mestayer to continuously improve NAD treatment protocols for various clinical indications and further research in NAD therapies.

  72. Jeremy C says:

    is it possible to get NAD intravenously in Australia?


    1. Alicia says:

      I also would like contact info for the doc in Louisiana.

    2. It’s not currently available in Australia. It’s not approved by the Australian government and importation is illegal. Hopefully, the Australian government will change that since Australia is leading some of the research in NAD⁺.

  73. Angela says:

    Hey Ben —

    Loved the podcast– really interesting stuff! The Dr’s mentioned in the podcast that there are some human clinical trials coming up testing the NAD infusions. It there more information about enrollment in those trials or where they may be held? I haven’t checked their websites yet so I’ll look there but I was just looking for a little more info . Thanks for all you do!! Love your show

    1. Clinical trials are in their early stages. The NAD Treatment Center will be involved in these studies. You can contact them at [email protected] and leave them your contact information and they will contact you when clinical trials begin.

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