An Interview With “The Smartest Physician On The Planet”: Crazy Biohacking Stacks For Cognitive Function, Microdosing CBD, The Rolls Royce Of Jet Lag Hacking & Much More.

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Dr. Ted Achacoso attained a college degree in biology at the age of 18 and a doctor of medicine at the age of 22. He is the founding pioneer of the clinical practice of Health Optimization Medicine and Practice (HOMe/HOPe), which is the detection and correction of imbalances at the level of the metabolome.

He was mentored by Thierry Hertoghe, the founding pioneer of anti-aging medicine and nutritional medicine (Dr. Ted is double board-certified, Paris) as well as William S. Yamamoto, artificial intelligence researcher and the founding pioneer of Medical Informatics. He was also mentored by D. Wayne Silby, the founding pioneer of Socially Responsible Investing and Finance and by three Philippine pioneers in interventional neuroradiology, neurology, and pharmacology/toxicology.

Dr. Ted is based in Washington, DC, maintains a tricontinental HOMe practice (North America, Europe, Asia), and performs HOMe/HOPe lecturing and mentoring to doctors and practitioners. He provides international corporate consulting activities involving nutritional supplement formulation and the establishment of metabolomics, mitochondria, and microbiota laboratories. He strongly suspects that this world is an illusion projected as a hologram by the human biocrystal, and pushes to create deliberately sustainable, happy dreams instead of nightmares.

Dr. Ted has trained, researched, and worked in many different fields:

  • Interventional neuroradiology and pharmacology in Manila;
  • Medical informatics and artificial intelligence in Washington, DC;
  • Scientific advisor to local venture and global institutional investment funds in Bethesda, MD;
  • As Founder and Chief Technology Officer of a group communication and collaboration software company in Rosslyn, VA (He created the first wireless mobile groupware);
  • As a quant trader for an incubator hedge fund in Rehoboth Beach, DE;
  • In Anti-Aging Medicine and Nutritional Medicine in Paris, Brussels, Monte Carlo.

His representative body of work includes a book containing the first-ever neural circuitry database (or the first-ever “connectome”) for an organism (C. elegans), journal articles, US patents, software, grants, and recorded interviews, webcasts, and speaking engagements in the areas of:

  • Artificial ethology, computational neuroethology, biomathematical modeling of nervous systems, and computability of consciousness;
  • Medical informatics, medical decision-making, connectionist systems, and expert systems;
  • Computer-assisted imaging, edge detection algorithms, and telehealth;
  • Virtual group dynamics, communication and collaboration methods including the first wireless groupware systems;
  • Parallel, cluster, cloud, and distributed emergent computing;
  • Predictive complex adaptive system modeling of financial time series.

During this discussion, you'll discover:

-The homemade nootropic Dr. Ted took before the interview with Ben…8:30

-Whether or not Dr. Ted is really the smartest physician alive…11:35

  • He's pretty darn close (1 in a billion)

-What is Health Optimization Medicine (HOMe) and Health Optimization Practice (HOPe)…12:45

  • HOMe is intended for physicians; HOPe is intended for practitioners
  • The goal is for there to be more practitioners than physicians
  • Dr. Ted was an interventional neuroradiologist (spoke brains for a living)
  • Retrained in Europe in nutritional medicine in 2009; fields such as epigenetics, microbiota, etc. were becoming popular in the U.S.
  • Metabalomics: Studying the metabolites produced during different chemical processes in the body
  • Technology allows treating actual fundamental cells, versus symptoms at the organ level
  • HOMe represents a more sophisticated “dashboard” to examine the body
  • Our metabolites' “golden years” are between the ages of 21-30
  • Separate test for hormones (ideally blood)
  • Why you can't treat/adjust just hormones
    • They're all in a network
    • Causes imbalance, brain receives and gives improper signals
  • Network perspective vs. artificial intelligence

-Dr. Ted's book about artificial intelligence and “connectomes”…27:55

  • He was made to choose between studying the computability of consciousness and beauty
  • Was banned by the powers that be at M.I.T. (later apologized)
  • Now referred to as “Deep learning” (marketing is king)
  • We're too DNA centric

-The 7 “pillars” of Dr. Ted's practice…35:45

  • Clinical and therapeutic metabalomics: detection and correction
  • Epigenetics: “Genes are not your destiny”
  • Bioenergetics (mitochondria): Symbiotic relationship with our environment
  • Microbiota (gut immune system)
    • 78% of your bacteria are in your gut
    • They teach your immune system what's foreign, what's not
    • People born via c-section are more prone to allergies, immune diseases
    • Some c-sections, gauze is dipped in vagina, then rubbed on the head after birth
  • Exposomics: The sum total of your exposure to your own lifestyle and environment (including in utero)
    • Shows how your environment interacts with your genome to produce phenome (not phenotype)
    • Detox protocols:
      • Targeted supplementation
      • Gut cleanup
      • Phototoxicity (blue light isn't all bad)
    • V-Moda Fader Earplugs
  • Chronobiology
  • Evolutionary medicine

-The “Rolls Royce” for hacking jet lag and tips for optimizing circadian biology…59:50

  • Hormone balancing
  • One “anchor” meal that is constant between time zones
  • Erythropoietin
  • Sleep hygiene:
    • “Your day begins at the time you fall asleep”
    • Treat your sleep as the first item on your list, not the last thing you do in the day
    • Oura ring

-Dr. Ted's guidance on diet…1:12:20

  • “Eating window” vs. “fasting window”
  • Complete everything in one day
  • Snowball effect (eat first and feel good, then get to work)
  • Remove sensitive foods right away
  • Dr. Ted's personal diet: Micro-nutrient optimized, macro-nutrient targeted
  • Make your fattiest meal your first meal; second meal high fiber and carbs; third meal have protein
  • Dr. Ted's morning coffee:

-And much more!

Click here for the full written transcript of this podcast episode.

Resources from this episode:

Dr. Ted says regarding his IQ: I range from 186 (bad day) to 210 (good day) in the various tests, but I average 190 on Wechsler (15 Standard Deviations) and I average 196 (16 SD) on Stanford Binet on repeated tests, thus, one in a billion rarity calculation for me for both (see online table here):
With my range of results and an 8 billion population, my range of results still have the target values  (195 for Wechsler and 201 for Stanford Binet) for a 1 in 8 billion rarity, hahaha! As you can see here, Mensa cut-offs for both Wechsler and Stanford Binet tests (as equivalent of the Mensa test, which is percentile-ranked) is 130. So really, not the 200 club as it is erroneously known:

Blue Cannatine Smart Troche

Health Optimization Medicine website

– The BioBalance Institute

– Dr. Ted's Facebook page

– Ay's Neuroanatomy of C. Elegans for Computation

– Pharmaceutical grade methylene blue


– Nicotine

– Ion Profile with 40 Amino Acids by Genova Diagnostics

– DUTCH hormone panel

– GI Effects Comprehensive Profile – 3 Day Stool

– JOOVV Photobiomodulation Panel

– V-Moda Fader Earplugs

– Thorne Biogest + SEED Probiotics

– Portable oxygen concentrator

– Oura ring

– The peptides podcast with Jean Francois Tremblay

– MiCacao chocolate and Omica Organic Stevia Ben adds to his coffee

– Parasym Plus

– Mucuna pruriens

– 5-HTP

Episode Sponsors:

Kion: My personal playground for new supplement formulations. Ben Greenfield Fitness listeners receive a 10% discount off your entire order when you use discount code: BGF10.

Four Sigmatic: I’ve been using Four Sigmatic products for a while now and I’m impressed by the efficacies of their mushroom products. I use them. I like them. I support the mission! Receive 15% off your Four Sigmatic purchase when you use discount code: BENGREENFIELD

Do you have questions, thoughts or feedback for Dr. Ted or me? Leave your comments below and one of us will reply!

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24 thoughts on “An Interview With “The Smartest Physician On The Planet”: Crazy Biohacking Stacks For Cognitive Function, Microdosing CBD, The Rolls Royce Of Jet Lag Hacking & Much More.

  1. Terry says:

    Where can we get the metabolite testing done?

  2. Allen Warner says:

    If you’re already on prescribed medication or affected by continual sickness.
    If you unluckily suffering one of the condition then you need to visit you doctor before the usage of any supplement motive it could damage you.

  3. CC says:

    Where can I find a practitioner in USA areas North Carolina or Georgia ??

    1. I recommend posting this to the Kion Community. It’s a completely free online community of like-minded people who both have advice and are seeking advice.

  4. Claudio says:

    Hi im kind of new to a lot of this stuff and I’m looking into incorporating probiotics into my daily regimen. It seems like you suggest taking the Thorne biogest along with the seed probiotics. I have a few questions regarding this. 1) What is the difference between these two? 2) Do you think it’s really necessary to take both? 3) If you had to suggest taking only one of the two as a daily supplement (budget constraints), which would you recommend? 4) Is there anyway to get the same benefits of either the Thorne or Seed products via regular foods?

    Thanks for all that you do and great podcast!

    1. Both are great… This kinda comes back to the idea of Bio Individuality. If you can only afford one, you can't really go wrong with either. I'd suggest try one and note results.

    2. I really like both Thorne and Seed, so if you are in a situation to choose, you really can't go wrong… I would recommend doing some research between the two before deciding which will most directly meet your needs. Fermented foods are also a great way to obtain probiotics and a certain number gut health benefits.

  5. Richard Fitswell says:

    With reference to micro-dosing 1P-LSD, what form are you buying, how long does it keep, and what would you tell a beginner to micro-dosing about it?

    1. Matt says:

      You can buy any form. I think that buying the 20mcg blotters is easiest. Just cut then in half and take 10mcg. One microdose every 3 days is the Fadiman protocol. But I actually like 5mcg the most I think I’ve reached some kind of reverse tolerance to the stuff.

      Also there is a Reddit thread on microdosing. Just Google it. Ben has also discussed these same things but I’m sure he going his information in the same places as everyone else

    2. I can't dive into that too deeply, but my recommendation would be to respect it and use in moderation.

  6. Matt says:

    We need some answers, how do we contact Dr Ted because he isn’t responding here or on his company website

  7. Jeff says:

    Just some QA on the links: the seed probiotic link goes to, should this be The amazon search term for portable oxygen concentrator is defined as “portable oxygen concentraor” which yields no results.


  8. Paarth says:

    Hey Ben,

    You mentioned going to Manila at some point. Would recommend Greenbar Cafe. It’s all vegan (I know that’s not your bag, but..) and the food is absolutely incredible.

    Thanks for all that you do for us.


  9. Arete says:

    Great framework for thinking about health optimization.

    He takes a dizzying array of supplements. Would have loved to hear how a few of these fit into his brilliant framework…

  10. J~ says:

    Where is the transcript for this podcast?

    1. It is available now… Always takes a couple days after the episode release.

  11. Matt says:

    Wondering why Ted Achacoso does not have a Wikipedia page. Where can we check his bona fides through a neutral third party?

    1. Shekhar says:

      You’ll have to do some digging to find info on Dr. Ted.

      Here’s some stuff….

      1) He did pioneering work in neuroscience/artificial intelligence:

      a)He coined the terms artificial ethology and computational neurology ethology.
      Achacoso, Theodore B. & Yamamoto, William S.”Artificial Ethology and Computational Neuroethology: A Scientific Discipline and Its Subset by Sharpening and Extending the Definition of Artificial Intelligence.” Perspectives in Biology and Medicine, vol. 33 no. 3, 1990, pp. 379-390

      b) He took the illustrations of the neural connections of C. elegans and somehow figured out how to represent them in matrix form —> and created the first-ever neural circuitry database (“connectome”) for an organism.

      2)He created the first wireless groupware systems:

      Patent –

      article from Jan 31, 2000
      “Washington-based GroupServe, the first developer of wireless groupware systems, has received $1 million in a round of angel investment led by ForceNine, a capital firm for early-stage telecommunications companies”

      “Investors with foresight get it,” explained Achacoso. “The next big thing is putting the Internet in your pocket. The next, next big thing is to make it actually useful. GroupServe makes the pocket Internet useful by providing on-the-fly, wireless group communication and collaboration for mobile professionals.”

      1. Shekhar says:

        *computational neuroethology

  12. John says:

    Hi Ben,

    I listened to the podcast and reviewed the methylene blue research paper on dosages given, however, Dr. Ted didn’t mention the specific dosage he was using. He mentioned “100 mg” as used in studies but not what he dosed with. Any idea? Thanks.

    1. Matt says:

      I want to know this too… Because MB is supposed to be used within a specific dosing range and Ted likes microdoses, which would lead me to believe that he does .5mg/kg dosing.

      The standard range seems to be 0.5–4 mg/kg. But I don’t know how he can just put this stuff in his mouth it probably stays blue for days. I just put powdered MB into a capsule… I want to know about this nicotine+ ,CBD trokie.

      My only gripe is how Ben will link random things or just take you to an Amazon search of said supplement instead of recommending a specific one. Like the trokie in the show notes is not the same as the trokie that Ted mentioned. Not even close

      1. Randy James says:

        So based on the .5 mg/ kg recommendation, how many micrograms would a 160 lb person take?

        1. Doober says:

          36 milligrams. 160/2.2=72.72kilograms … 72.72/2=36.36

  13. Andrew says:

    Wow, what an intense podcast! Very motivational and inspiring. What type of hgh is Dr. Ted taking? And how many IU?

    What type of testosterone does he take?

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