Caffeine Evolved: The New Darling Molecule Of The Energy Supplement Industry – Everything You Need To Know About “Paraxanthine” With Daniel Solomons & Shawn Wells.

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Biohacking, Body, Diet & Nutrition, Health & Wellness, Podcast, Podcast-new

Are you tired of feeling jittery, anxious, and restless after downing your third cup of coffee?

Enter paraxanthine – the “magical little molecule” that promises to take your energy and focus to the next level without any of the negative effects of caffeine.

Paraxanthine is like caffeine's cool, collected cousin who shows up to the party and steals the show. It's a natural metabolite of caffeine that's been scientifically engineered to enhance your cognitive function and athletic performance without the pesky side effects that come with consuming too much caffeine.

And trust us, I'm not exaggerating when I say that paraxanthine is in a league of its own. My friend Shawn Wells, aka “The World's Greatest Formulator,” introduced me to this game-changing ingredient, and I've been singing its praises ever since.

I interviewed Shawn on two previous podcast episodes:
Today, I invited Shawn back to talk about his new Update energy drink featuring paraxanthine (you can click here to get Update Energy Drink and use code BEN to save 10%). Shawn is joined by the CEO and his co-founder of Update, Daniel Solomons, who spent more than three years working with partners to develop the groundbreaking formula.

Shawn Wells, MPH, LDN, RD, CISSN, FISSN is a leading nutritional biochemist and expert on health optimization. Now known as the Ingredientologist (the scientist of ingredients), he has formulated over 1,000 supplements, food, beverages, and cosmeceuticals and patented 25 novel ingredients. Formerly a Chief Clinical Dietitian with over a decade of clinical experience, Shawn has counseled thousands of people on natural health solutions such as keto, paleo, fasting, and supplements. He has also personally overcome various health issues, including Epstein-Barr Virus, Chronic Fatigue Syndrome, Fibromyalgia, depression, insomnia, obesity, and a pituitary tumor.

With appearances on national radio programs, morning television, and documentaries, Shawn's expert insights have helped countless health-conscious individuals manage stress, boost their performance, and experience sustained energy through practical holistic solutions.

During our discussion, you'll discover:

-Shawn & Daniel's Update energy drink…05:30

  • Paraxanthine
    • Like caffeine
    • No crashes
    • Better focus
    • More confidence
    • Doesn’t interrupt sleep
  • Ben’s experience with paraxanthine
  • Shawn Wells and Daniel Solomons
  • Update Energy Drink (use code BEN to save 10%)

-What is paraxanthine?…09:58

  • Main metabolite of caffeine
    • Around 80% is paraxanthine
  • Caffeine breaks into 3 metabolites
    • Paraxanthine
    • Theobromine
    • Theophylline
  • Why hasn't it been isolated earlier?
  • Slow and fast caffeine metabolizers
    • Many people need 3 days to eliminate caffeine from the system
  • Caffeine is an insect repellent
  • Paraxanthine doesn’t have the side effects of caffeine; the more you use it, the better it works

-The afterglow effect…19:11

  • Ben’s experience with paraxanthine and sleeping
  • No crash, afterglow effect
  • No toxicity of the other coffee compounds

-The potentiation of nitric oxide transmission…21:50

  • A link to increased dopamine release
  • PDE (phosphodiesterase) compounds
  • PDE-9 – greater nitric oxide release
    • Dopamine increase
    • All neurotransmitters potentially potentiated
  • Currently exploring different dopaminergic impacts; similarities to psychedelics
  • Impact on erectile dysfunction may be possible but not yet studied
  • Research about paraxanthine and exercise performance
    • No side effects compared to caffeine
    • Improved endurance and resistance to fatigue
    • Overall improved performance

– Is Enfinity the brand name for paraxanthine?…26:26

  • Enfinity is the patented brand name 
  • ING²
  • Paraxanthine provides a very different experience than caffeine
  • Paraxanthine capsules combined with coffee
    • Like taking pure water and adding dirty water
    • There are negative effects when the two compounds are taken together

-The background on Update…28:45

  • Update Energy Drink (use code BEN to save 10%)
  • Most energy drinks have always been caffeine plus sugar; not very desirable
  • Daniel wanted to create an energy drink with nootropics
    • Reached out to Shawn
    • Wanted good taste, better performance, less side effects
    • Only natural sweeteners
    • Nootropics and large amounts of paraxanthine
  • Flavors like Mandarin, Berry, Peach, Lime
  • It took 2 years to create the flavors
  • Nootropics are tough to work with flavor-wise
  • Sweeteners
    • Combination of allulose and stevia glycosides
    • Allulose is non-glycemic sugar, very low caloric value
    • Stevia – combination of different forms for better taste
  • Stevia has 2 different forms with slightly different flavor profile
  • Podcasts with Shawn Wells:
  • The dark side of flavor science

-The components of Update…40:14

  • 300 mg of paraxanthine
  • Nootropics combined with paraxanthine
    • Taurine (calming and neuroprotective effect)
    • N-Acetyl L-Tyrosine(dopamine precursor)
    • Alpha GPC (a precursor to acetylcholine for memory formation)
    • L-Theanine (enhances alpha brain waves)
    • 5-HTP (a precursor to serotonin)
    • Vitamin B12 (Methylcobalamin)

-How can you take Update later in the day and still be able to sleep?…45:03

  • Shorter half-life
  • No toxic compounds
  • Beneficial “side-effects” (nitric oxide, BDNF, etc.)

-What's the best time to consume Update?…47:08

  • Depends on your needs

-What is in the packaging/cans?…48:01

  • Standard can, the safest cans on the market

-Biohacking with Daniel and Shawn…49:40

-And much more…

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Click here for the full written transcript of this podcast episode.

Resources from this episode:

Daniel Solomons and Shawn Wells:

– Podcast:

– Other Resources:

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Ask Ben a Podcast Question

11 thoughts on “Caffeine Evolved: The New Darling Molecule Of The Energy Supplement Industry – Everything You Need To Know About “Paraxanthine” With Daniel Solomons & Shawn Wells.

  1. RIck F says:

    How does Paraxanthine affect gray matter in the brain?

    Caffeine reduces gray matter. REF:

    Does Paraxanthine do the same?

  2. Steve Marshall says:

    Thoughts on this ? about caffeine
    Just as well we are not little bugs/insects lol

    1. Steve Marshall says:

      Another interesting thing:

  3. Gloria in excelsis Deo says:

    How about Update for teen athletes (ages 15 and 17)?

    Okay to drink two a day ( for adults)?

  4. Mark Campbell says:

    Adding to these replies, 5-HTP does not work for me so this drink is out, how/when an isolated form of paraxanthine?

    Also – BEN – you mentioned in the podcast about amino acids and sleep supplements competing over l-tryptophan, can you expand on that a bit please?

    1. Ben Greenfield says:

      Hi Mark ! 🙌 Ben’s social media assistant here 😊. That’s a great question! While I do not have an answer for this at the moment, I have added your question to the list of candidates for Ben to potentially answer in one of his upcoming Q&A episodes so stay tuned! Thanks again for reaching out and be sure to make it an awesome Wednesday 💪

  5. Thomas Dineen says:

    My second day of the update drink.. it’s ok but it’s not my Starbucks.. I think I need more energy… this has more of a calming effect on me … maybe I can mix with super coffee to get boost. ?
    I know it seems counterintuitive. I ordered more to give it a fair shake.

  6. R says:

    Same here!!!! How do we get the isolated form in a powder??? The cans make it difficult to travel if you don’t check bags. Please advice.

  7. David R says:

    I know I’m not alone here, how long will enfinity be leased to these pre-formulated beverages, because we all just want isolated paraxanthine. I’ve tried the update drink and it is nice but we’re all experimenters here.

    1. Darin says:

      This. This. This. I’ve been looking everywhere for an isolated version. I’d like to avoid the nootropic stack thats being added in the products its packaged with.

      1. thomas alderson says:

        Yup, yup, yup.

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